Theoretical Optoelectronics in Medicine

Garant předmětu:

Jan Vrba

Lecturer:

Vladimír Blažek, Jan Vrba

Tutor:

Vladimír Blažek, Jan Vrba

Supervisor:

Department of Electromagnetic Field

Synopsis:

The course gives to doctoral students from different disciplines the opportunity of both highly theoretical studies and numerical simulations of interactions of electromagnetic waves in the visible part of the spectrum (and adjacent UV and IR bands) with biological tissues. And to learn about modern optoelectronic sensor concepts and their applications in the

field of medical therapy and diagnostics. Interdisciplinary topics will be discussed and focused on the benefits and current applications of optoelectronics in medicine. Important definitions (such as radiation intensity, etc.) will be formulated and important methods will be described, in particular: radiometry, photometry, eye as a radiation detection field. UV, VIS, NIR spectroscopy, interferometry, scattering measurements, integration of spherical theory, etc.

Emphasis will be placed on modern theoretical approaches (i.e. mathematical and physical models), e.g. calculation of the light intensity distribution in biological tissue, theory of radiation transmission (e.g. theory and model Kubelka-Munk), etc. Students will be acquainted with the possibilities of numerical simulations of the given problems by aid of

modern SW products (like e.g. COMSOL Multiphysics, SEMCAD / Sim4Life, CST, etc.) which are working based on numerical methods FDTD, FEM, MoM, Monte-Carlo etc. Operating principle of the optoelectronic reflective and transmissive sensors. Measurement concepts for noninvasive detection of peripheral blood volume dynamics, clinical examples and typical examination tests. Principles and applications of functional optical imaging techniques: optical biopsy, IR Diaphanoscopy, IR thermography, Laser Doppler perfusion imaging (LDPI), Photoplethysmo-graphy imaging (PPGI), optical coherence tomography (OCT).

Requirements:

Syllabus of lectures:

1. Introduction, Maxwell equation in visible plus IR and UV frequency bands.

2. Theoretical basis of optics from a biomedical engineering perspective

3. Light and life, ecological, biophysical and metrological aspects of optoelectronics

4. Biological effects of UV, VIS and IR radiation, interactions and hazards, radiation protection

5. Biophysics of light perception

6. Theory of tissue optics, optical parameters of biological samples (measurement metohods)

7. Light propagation in tissue – numerical simmulations by aid of FDTD, FEM and Monte-Carlo methods

8. Computer-aided evaluation of light propagation in human body (Sim4Life, Comsol Multiphysics, etc.).

9. Human haemodynamics - biophysical fundamentals and non-invasive measurement strategies/techniques

10. Optoelectronic sensors – description of theoretical principles and implementations, components, design features

11. Theory and implementation of quantitative photoplethysmography (PPG)

12. Sensors for transcutaneous determination of blood-oxygen saturation

13. Optical imaging systems

14. Methods for functional medical diagnostics

Syllabus of tutorials:

Study Objective:

Study materials:

[1] Bansal A. et al.: „Wearable Organic Optoelectronic Sensors for Medicine“. Wiley 2016

[2] Kasap S.O.: Optoelectronics & Photonics:Principles & Practices: International Edition (Kindle edition), 2013

[3] Blazek, V., Schultz-Ehrenburg, U.: Quantitative Photoplethysmography. Basic facts and examination tests for evaluating peripheral vascular functions. VDI Verlag, Düsseldorf 1996, ISBN 3-18-319220-9

[4] Bronzio, J.D.: The Biomedical Engineering Handbook. 2nd ed,, Volume I., Springer Verlag, Heidelberg 2000, ISBN 3-540-66351-7

[5] Cheong, W.F. et al.: A rewiew of the optical properties of biological tissue. QE 26 (1990), 2166-2185

[6] Cooper, J., Cass, T. (eds): Biosensors. 2nd ed., Oxford University Press, Oxford 2004, ISBN 0-19-963846-2

[7] Fraden, J.: Handbook of Modern Sensors. 3rd ed., Springer Verlag 2004

[8] Harsanyi, G.: Sensors in Biomedical Applications. Fundamentals, Technology & Applications. CRC Press, Boca Raton 2000

[9] Prasad, P.N.: Introduction to Biophotonics, Wiley, 2003, ISBN 0-471-29770-9

Note:

Time-table for winter semester 2024/2025:

Time-table is not available yet

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans:

• Doctoral studies, daily studies (compulsory elective course)
• Doctoral studies, combined studies (compulsory elective course)