Structure and Function of Biomolecules

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Solid State Engineering

Synopsis:

Knowledge of macromolecular structure is crucial for the understanding of its function. The subject is focused on the introduction to building blocks of macromolecules, overall structure and its structure:function relationship including macromolecular complexes.

Requirements:

High school chemistry.

Syllabus of lectures:

1. Chemical bonds, proteins, saccharides, nucleic acids

2. Primary, secondary, tertiary and quarternary structure of proteins

3. Protein folding

4. Structure of nucleic acids, interaction motives of protein:nucleic acids complexes

5. Basic biophysical methods, methods of structure determination of macromolecules

6. Macromolecular crystallography

7. Structure of enzymes, drug design

8. Structure of viruses and viral proteins

9. Structure and function of membranes and membrane proteins

10. Structure and function of components of immune system

11. Large macromolecular complexes (respiration, transcription, translation)

Syllabus of tutorials:

Individual work covers composition of several protocols according to the manual and independent analysis of an actual structure biology paper.

Study Objective:

Goals of study are following: an independent analysis of a macromolecular structure, understanding of publications related to structures of macromolecules.

Study materials:

Compulsory literature:

C. Branden, J. Tooze, Introduction to Protein Structure 2nd Edition, Garland Science, New York, NY, 1999.

A. Liljas, L. Liljas, J. Piskur, G. Lindblom, P. Nissen, M. Kjeldgaard, Textbook of Structural Biology, World Scientific Publishing Co. Pte. Ltd., Singapore, 2009.

Optional literature:

B.Alberts, D. Bray, A. Johnson, J. Lewis, M. Raff, K Roberts, P. Walter, Základy buněčné biologie, Espero Publishing, s.r.o., Ústí nad Labem, 2005.

Z. Vodrážka, P. Rauch, J. Káš, Enzymologie, Vysoká škola chemicko-technologická, 1998.

Note:

Further information:

https://kiplwww.fjfi.cvut.cz/drupal7/?q=11SFBM

No time-table has been prepared for this course

The course is a part of the following study plans:

• Jaderná chemie (elective course)
• BS Matematické inženýrství - Matematické modelování (elective course)
• BS Matematické inženýrství - Matematická fyzika (elective course)
• BS Matematické inženýrství - Aplikované matematicko-stochastické metody (elective course)
• BS Informatická fyzika (elective course)
• BS Aplikace softwarového inženýrství (elective course)
• BS Aplikovaná informatika (elective course)
• BS jaderné inženýrství B (elective course)
• BS Jaderné inženýrství C (elective course)
• BS Dozimetrie a aplikace ionizujícího záření (elective course)
• BS Experimentální jaderná a částicová fyzika (elective course)
• BS Inženýrství pevných látek (elective course)
• BS Diagnostika materiálů (elective course)
• BS Fyzika a technika termojaderné fúze (elective course)
• BS Fyzikální elektronika (elective course)
• BS Jaderná chemie (elective course)
• Fyzikální inženýrství - Inženýrství pevných látek (elective course)