- Garant předmětu:
- Department of Biomedical Technology
Basic concepts of systemic approach to the human organism. Functional organization of living systems. Integrated functions and importance of systems interesting biomedical technicians and engineers. Principles of experimental and investigative methods used in physiology and medicine. Examples of modern technological contributions to medicine.
- Syllabus of lectures:
1 SYSTEMIC APPROACH TO THE HUMAN ORGANISM
Functional organization of living organisms. What is life? Thermodynamics of living systems; evolutionary and ecological aspects.
Biological transports: principles and classification. Bioenergetics.
From cell to organism: functional hierarchy and coordination in the human organism. Experimental approach and modelling.
Adaptation: physical and chemical parameters compatible with survival, concept of homeostasis.
2 EXCHANGES – BASIS OF LIFE
Blood circulation and gas exchanges. Functional interrelationships and regulatory mechanisms. Ischemia, hypoxia, oxidative stress. Technological supports.
Assimilation and excretion.
Digestive motility: investigation (special lecture: from idea to clinical use).
Renal exchanges: transport of solutes and water. Hemodialysis.
Information processing: principles of intercellular communication.
Neural signals: origins, coding, propagation, storage, modulation.
Neuro-muscular system: from motor unit to speech.
3 INTEGRATIVE MECHANISMS
Homeostasis of vital parameters.
Adaptation to physical effort.
Behaviour: Introduction into cognitive functions. Man – zoon politicon.
- Syllabus of tutorials:
Two experimental sessions (4 hours):
1.Cell physiology: osmotic resistance of erythrocytes.
2.Human physiology: energy metabolism, ergometry.
- Study Objective:
- To revise physiological knowledge from the point of view of engineers.
- To understand principles of investigative methods used in physiology and medicine.
- To realize the importance of integrative approach to functional systems with respect to application in technological development.
- To stimulate search for open medical problems and their solutions.
- Study materials:
 P. Kucera: Documents and outlines distributed in advance to lectures.
 Lauralee Sherwood: Human physiology, From cells to Systems, 9th
edition, 2016. Can be downloaded free of charge (Academia.edu)
 W. Boron, E.L. Boulpaep Medical Physiology, 3d edition,
 A.C. Guyton, J.E. Hall Textbook of Medical Physiology, 13th edition,
- Further information:
- No time-table has been prepared for this course
- The course is a part of the following study plans: