Toxicology

Course guarantor:

Ján Kozempel

Lecturer:

Ján Kozempel, Martin Vlk

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

Overview of basic toxicology, containing general and special toxicology, toxicological data, legislation and basic aspects of chemical compounds handling. In general toxicology aspects of toxicity, metabolism, biodistribution and elimination has been described, as well as toxicological effects, evaluation of toxicity, indexes, and biological tests. In special toxicology part selected group of organic compounds, inorganic compounds, natural compounds and warfare were described from toxicity behaviour. In legislation part REACH, international and national regulation is described.

Requirements:

The lecture is intended for students of all chemical branches. The basic knowledge of physico-chemical, organic, and inorganic chemistry and biochemistry is supposed. The exam is a test, to meet the requirement is more than 60% of the possible points.

Syllabus of lectures:

1.General toxicology, basic terminology.

2.Biology, physiology, mechanism of uptake and distribution.

3.Biotransformation and elimination of xenobiotics.

4.Basic toxicology effects, factor, indexes.

5.Experimental toxikology.

6.Quantitative and qualitative relation between structure and biological effects.

7.Toxicology of inorganic compounds.

8.Toxicology of organic compounds and organometals.

9.Analytical and predictive toxicology, ecotoxicology.

10.Legislation and regulation, REACH.

11.Basic safety standards in chemical laboratory.

Syllabus of tutorials:

Study Objective:

The aim of lecture is to give connected survey of basic areas of toxicology. The lecture is opened by common toxicology, continued by special toxicology and chapters from special areas of toxicology close it.

Study materials:

Key Literature:

1.Selected articles in Toxicology, Elsevier Journal, 2000-2019

2.E. Hodgson (Ed.): A Textbook of Modern Toxicology, 4nd Ed., New York, Wiley, 2010

Recommended Literature:

3.C. Klaassen: Casarett & Doull’s Toxicology: The Basic Science of Poisons, 8th Ed, New York, McGrawHill, 2013

Note:

Time-table for winter semester 2024/2025:

Time-table is not available yet

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans:

• Jaderná chemie (compulsory course in the program)