Physiology and Pathophysiology

The course is not on the list Without time-table
Code Completion Credits Range Language
17ABFFPF Z,ZK 2 2P+2C English
Garant předmětu:
Department of Health Care Disciplines and Population Protection

This subject aims to provide an overview of the basic mechanisms of pathophysiological process in development of major body systems disorders. This course provides the understanding of the common disorder effects on normal structure and function, and so expands knowledge in basic anatomy and physiology previously studied. At the end of course the students has orientation in the pathophysiology of diseases in the major organ systems (cardiovascular, gastrointestinal, renal, and respiratory) and understand the cellular mechanisms responsible for impaired function.



1. To attend lectures and practical classes (absences are acceptable for serious reasons only (max. 3 absences per semester) and must be apologized and recompensed).

2. To have protocols from classes.

3. Supervisor may control preparedness of student by tests (at least 50 % of right questions), discussion, presence of work papers.

4. To prepare an oral presentation (list of topics will be given by supervisor, presentation for 10 min).


1. To have Assessment.

2. Test (30 questions, quantity of right questions - at least at 50 %, number of right answers in test question: 0, 1 or more).

Syllabus of lectures:

Physiology and pathophysiology of cell. Inflammation. Regeneration. Genetic disorders. Cancers.

2. Homeostasis. Pathophysiology of homeostasis.

3. Metabolism. Pathophysiology of metabolism.

4. Physiology and pathophysiology of cardiovascular system.

5. Physiology and pathophysiology of blood.

6. Physiology and pathophysiology of respiratory system.

7. Physiology and pathophysiology of digestive system.

8. Physiology and pathophysiology of urinary system.

9. Physiology and pathophysiology of musculoskeletal system.

10. Physiology and pathophysiology of endocrine system.

Syllabus of tutorials:

Introduction. Cell death. Inflammation. Genetic disorders. Cancer.

2. Physiology and pathophysiology of tissue fluids. Pathophysiology of homeostatic reactions.

3. Physiology and pathophysiology of metabolism.

4. Physiology and pathophysiology of heart and vessels. Pathophysiology of blood.

5. Physiology of respiratory system. Disorders of ventilation and perfusion.

6. Functions of digestive system. Pathophysiology of organs of digestive system.

7. Functions of kidneys. Pathophysiology of kidneys. Pathophysiology of other urinary organs.

8. Functions of muscular cells. Pathophysiology of muscles.

9. Main hormones, their functions. Pathophysiology of endocrine gland. Pathophysiology of stress reactions.

10. Assessment.

Study Objective:
Study materials:

1.HALL, John E.. Guyton and Hall Textbook of Medical Physiology. 13th rev. ed. London: Elsevier Health Sciences, 2015, 1168 p. ISBN 978-14-557-7005-1.

2.PORTH, Carol. Essentials of Pathophysiology. 4th ed. New York: Wolters Kluwer, Lippincott Williams & Wilkins, 2014, 1280 p. ISBN 1451194323.

3.HAMMER, Gary D. and Stephen J. McPhee. Pathophysiology of Disease. 7 th. ed. New-York: McGraw-Hill Professional, 2019, 784 p. ISBN 1259251446.

4.SILBERNAGL, Stefan and Florian LANG. Color atlas of Pathophysiology. 3rd ed. Stuttgart: Thieme, 2016, 448 p. ISBN 3131165537.

Further information:
No time-table has been prepared for this course
The course is a part of the following study plans:
Data valid to 2024-04-11
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