Physical Chemistry

Relations:

In order to register for the course F7PBBFCH, the student must have successfully completed the course F7PBBCHM in a previous semester.

The course F7PBBLT can be graded only after the course F7PBBFCH has been successfully completed.

The course F7PBBSPT can be graded only after the course F7PBBFCH has been successfully completed.

In order to register for the course F7PBBPTI, the student must have successfully completed the course F7PBBFCH.

Course guarantor:

Karel Roubík

Lecturer:

Karel Roubík, Martina Turchichová

Tutor:

Iveta Horáčková, Martina Turchichová

Supervisor:

Department of Biomedical Technology

Synopsis:

The course is aimed at clarifying the physicochemical principles of topics related to the profession of biomedical engineer and technician in clinical practice or research. The goal of the course is to provide students with the fundamentals of physical chemistry as they occur and are applied in the design of medical devices, in clinical research, or directly in clinical practice. The course demonstrates the direct application of theoretical principles in practice.

Requirements:

Conditions for obtaining credit:

Compulsory attendance, absences must be properly excused and made up.

Successful completion of two credit written papers (at least 50% of the points in both). Completion of all laboratory assignments, writing at least 60% of the entry tests for the assignments, and submitting the completed reports by the due date. One assignment may be substituted.

Course and evaluation of the exam:

The examination has a written and an oral part. The written part consists of a test in which there are questions to be answered by the students. The test must be written with a minimum score of 50%. Some questions may carry more weight in the assessment than others, for example those involving a numerical problem or requiring a complex approach to solving. Successful completion of the test is followed by an oral examination. If the results of the written part are sufficient for classification, the oral part of the examination may be waived. If the result of any part is graded F, the result of the examination is automatically F.

Syllabus of lectures:

1. Definition of the subject. 1. Basic principles of physical chemistry. Physical and chemical properties of substances.

2.The basics of thermodynamics. Laws of thermodynamics, chemical potential.

3.Nature and behaviour of substance systems - gases. Properties and structure, calculations of composition of gas mixtures, equations of state and state processes.

4.Nature and behaviour of systems of matter - liquids. Solutions. Dissolution, solubility. Properties of solvents.

5. Phase equilibria, multicomponent systems.

6.Vapour behaviour and properties, evaporation, saturated and superheated vapour. Principles of humidifiers and anaesthetic vaporizers, other applications in BMI.

7.Theory of electrolytic dissociation. Ionic strength of solutions.

8.Acidity and alkalinity of solutions, pH. Acid-base equilibria in biological systems.

9. Electrolysis. Conductivity of solutions and its measurement. Polarography.

10. Electrochemical potential, electrodes of the first and second kind. Electrochemical cell, concentration cell. Applications in BMI.

11. Redox electrodes. Electrodes in medicine (ECG, EEG, EMG, etc.).

12.Membranes - types, properties and applications. Osmosis and osmotic pressure.

13. Ion selective electrodes. pH measurement.

14. Sensors for measuring pH, pO2, pCO2 and SO2. Applications in BMI.

Syllabus of tutorials:

1. Concentration and pH calculations.

2. Calculation of pH.

3.Calculations of electrode potentials, cell voltages, conductivity.

4.Calculations of electrode potentials, cell voltages, conductivity.

5.Calculations of solubility, electrolysis.

6.Test I

7.Measurement of electrode potential.

8.Measurement of redox potential.

9.pH measurement.

10.Conductivity measurement.

11.Ion-selective electrode I measurement.

12.Ion-selective electrode measurement II.

13.Gas probe measurement.

14.Test II.

Study Objective:

To clarify the physicochemical principle of topics related to the profession of biomedical engineer and technician in clinical practice or research. The goal of the course is to provide students with the fundamentals of physical chemistry as they occur and are applied in the design of medical devices, in clinical research, or directly in clinical practice. The course demonstrates the direct application of theoretical principles in practice.

Study materials:

Note:

Time-table for winter semester 2024/2025:

	06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon
Tue	roomKL:B-330 Turchichová M. Roubík K. 08:00–09:50 (lecture parallel1) Kladno FBMI roomKL:B-230 Horáčková I. 14:00–15:50 (lecture parallel1 parallel nr.4) Kladno FBMI roomKL:A-007 Horáčková I. 14:00–15:50 (lecture parallel1) Kladno FBMI
Wed	roomKL:A-007 Horáčková I. 08:00–09:50 (lecture parallel1) Kladno FBMI roomKL:A-007 Horáčková I. 16:00–17:50 (lecture parallel1) Kladno FBMI roomKL:B-230 Horáčková I. 10:00–11:50 (lecture parallel1 parallel nr.2) Kladno FBMI roomKL:B-230 Horáčková I. 12:00–13:50 (lecture parallel1 parallel nr.3) Kladno FBMI roomKL:A-007 Horáčková I. 14:00–15:50 (lecture parallel1) Kladno FBMI roomKL:A-007 Horáčková I. 10:00–11:50 (lecture parallel1) Kladno FBMI
Thu
Fri

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans:

• Biomedical Technology (compulsory course)
• Biomedical Technology (compulsory course)