Theoretical Optoelectronics in Medicine
Code  Completion  Credits  Range  Language 

XP17TOM  ZK  5  2P+2C+4D  Czech 
 Course guarantor:
 Jan Vrba
 Lecturer:
 Vladimír Blažek, Jan Vrba
 Tutor:
 Vladimír Blažek, Jan Vrba
 Supervisor:
 Department of Electromagnetic Field
 Synopsis:

The course gives to doctoral students from different disciplines the opportunity of both highly theoretical studies and numerical simulations of interactions of electromagnetic waves in the visible part of the spectrum (and adjacent UV and IR bands) with biological tissues. And to learn about modern optoelectronic sensor concepts and their applications in the
field of medical therapy and diagnostics. Interdisciplinary topics will be discussed and focused on the benefits and current applications of optoelectronics in medicine. Important definitions (such as radiation intensity, etc.) will be formulated and important methods will be described, in particular: radiometry, photometry, eye as a radiation detection field. UV, VIS, NIR spectroscopy, interferometry, scattering measurements, integration of spherical theory, etc.
Emphasis will be placed on modern theoretical approaches (i.e. mathematical and physical models), e.g. calculation of the light intensity distribution in biological tissue, theory of radiation transmission (e.g. theory and model KubelkaMunk), etc. Students will be acquainted with the possibilities of numerical simulations of the given problems by aid of
modern SW products (like e.g. COMSOL Multiphysics, SEMCAD / Sim4Life, CST, etc.) which are working based on numerical methods FDTD, FEM, MoM, MonteCarlo etc. Operating principle of the optoelectronic reflective and transmissive sensors. Measurement concepts for noninvasive detection of peripheral blood volume dynamics, clinical examples and typical examination tests. Principles and applications of functional optical imaging techniques: optical biopsy, IR Diaphanoscopy, IR thermography, Laser Doppler perfusion imaging (LDPI), Photoplethysmography imaging (PPGI), optical coherence tomography (OCT).
 Requirements:
 Syllabus of lectures:

1. Introduction, Maxwell equation in visible plus IR and UV frequency bands.
2. Theoretical basis of optics from a biomedical engineering perspective
3. Light and life, ecological, biophysical and metrological aspects of optoelectronics
4. Biological effects of UV, VIS and IR radiation, interactions and hazards, radiation protection
5. Biophysics of light perception
6. Theory of tissue optics, optical parameters of biological samples (measurement metohods)
7. Light propagation in tissue – numerical simmulations by aid of FDTD, FEM and MonteCarlo methods
8. Computeraided evaluation of light propagation in human body (Sim4Life, Comsol Multiphysics, etc.).
9. Human haemodynamics  biophysical fundamentals and noninvasive measurement strategies/techniques
10. Optoelectronic sensors – description of theoretical principles and implementations, components, design features
11. Theory and implementation of quantitative photoplethysmography (PPG)
12. Sensors for transcutaneous determination of bloodoxygen saturation
13. Optical imaging systems
14. Methods for functional medical diagnostics
 Syllabus of tutorials:
 Study Objective:
 Study materials:

[1] Bansal A. et al.: „Wearable Organic Optoelectronic Sensors for Medicine“. Wiley 2016
[2] Kasap S.O.: Optoelectronics & Photonics:Principles & Practices: International Edition (Kindle edition), 2013
[3] Blazek, V., SchultzEhrenburg, U.: Quantitative Photoplethysmography. Basic facts and examination tests for evaluating peripheral vascular functions. VDI Verlag, Düsseldorf 1996, ISBN 3183192209
[4] Bronzio, J.D.: The Biomedical Engineering Handbook. 2nd ed,, Volume I., Springer Verlag, Heidelberg 2000, ISBN 3540663517
[5] Cheong, W.F. et al.: A rewiew of the optical properties of biological tissue. QE 26 (1990), 21662185
[6] Cooper, J., Cass, T. (eds): Biosensors. 2nd ed., Oxford University Press, Oxford 2004, ISBN 0199638462
[7] Fraden, J.: Handbook of Modern Sensors. 3rd ed., Springer Verlag 2004
[8] Harsanyi, G.: Sensors in Biomedical Applications. Fundamentals, Technology &amp; Applications. CRC Press, Boca Raton 2000
[9] Prasad, P.N.: Introduction to Biophotonics, Wiley, 2003, ISBN 0471297709
 Note:
 Timetable for winter semester 2024/2025:
 Timetable is not available yet
 Timetable for summer semester 2024/2025:
 Timetable is not available yet
 The course is a part of the following study plans:

 Doctoral studies, daily studies (compulsory elective course)
 Doctoral studies, combined studies (compulsory elective course)