Perspective Technologies for Implants and Biosensors

Course guarantor:

Petr Písařík

Lecturer:

Jan Mikšovský, Petr Písařík, Jan Remsa

Tutor:

Jan Mikšovský, Petr Písařík, Jan Remsa

Supervisor:

Department of Biomedical Technology

Synopsis:

The course is focused on promising technologies for implants and biosensors in medicine. The aim of the course is to get acquainted with the basic principles of commonly used technologies for implants and biosensors. The course covers methods of production and development, physical properties and their measurement, and methods of application in clinical practice.

Requirements:

As a standard, teaching takes place in contact form and the course ends with an oral exam, which is preceded by written preparation. If the number of students is less than 5, teaching can take place in the form of guided self-study with regular consultations. Furthermore, it is required to prepare a written study by the student on a given topic in the field. The condition for admission to the exam is the completion of two laboratory exercises (evidenced by a protocol signed by the student, the head of the exercise and the guarantor of the course). These protocols will be archived.

Syllabus of lectures:

Syllabus of lectures:

1. Difference between PVD and CVD deposition technologies, criteria for selection of deposition technologies. Main PVD and CVD thin film technologies, principles, advantages and disadvantages of PVD and CVD methods (layer growth rate, particle energy, pressure criteria, limitations, area size).

2. Steaming and sputtering methods (diode sputtering, magnetron RF, DC), principle, limitations.

3. Deposition methods - IBAD, ion plating. Deposition methods - MBE, ECR, LPE, sol-gel, CVD.

4. Lasers and their applications in materials research, technology graph - laser radiation intensity - laser pulse length.

5. Pulsed laser deposition, principle, advantages, disadvantages. Laser beam focusing (Gaussian beam, excimer laser, divergence, minimum spot, focusing length, beam quality and homogeneity).

6. Interaction of laser radiation with a target, models, femtosecond ablation. Transport of particles from the target - plasma cloud, Analysis and propagation of plasma cloud (CCD camera, placement of the substrate, the effect of pressure, spot). Analysis of layer properties - division of methods. Analysis of layers by XRD (Bragg Brentanno, rocking curve, ..), FTIR, Raman, NMR.).

7. Optical methods for characterization of layers (ellipsometry, transmission, optical transmittance and reflectivity, band gap, refractive index, microscopes, luminescence).

8. Mechanism of layer growth (Frankan der Merve, Volmer Veber, Stranski-Krastanov), homoepitaxy, heteroepitaxy.

9. Hybrid laser deposition systems (RF discharges, magnetrons), gradient and composite layers. MAPLE, organic layers.

10. Medical applications of laser thin films (HA layers, DLC, prosthesis coating, heart valves)

Syllabus of tutorials:

Syllabus of exercises (block form of teaching after 4 teaching hours):

1. Layer analysis - composition of XPS, ESCA, AES, WDX, PIXE RBS, SIMS, NMR

2. Layer analysis - morphology - SEM, AFM, STM, TEM, SNOM

Study Objective:

The course is focused on promising technologies for implants and biosensors in medicine. The aim of the course is to get acquainted with the basic principles of commonly used technologies for implants and biosensors. The course covers methods of production and development, physical properties and their measurement, and methods of application in clinical practice.

Study materials:

[1] D.B. Chrisey, G.K. Hubler: Pulsed laser Deposition of Thin Films, John Wiley, 1994.

[2] B.E.A. Saleh, M.C. Teich: Základy fotoniky, svazek 3, matfyzpress, Praha, 1995.

Note:

Time-table for winter semester 2024/2025:

Time-table is not available yet

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans: