Structure and Function of Biomolecules

Course guarantor:

Petr Kolenko

Lecturer:

Petr Kolenko, Tomáš Kovaľ

Tutor:

Petr Kolenko, Tomáš Kovaľ

Supervisor:

Department of Solid State Engineering

Synopsis:

Knowledge of macromolecular structure is crucial for the understanding of its function. The subject is focused on the introduction to building blocks of macromolecules, overall structure and its structure:function relationship including macromolecular complexes.

Requirements:

High school chemistry.

Syllabus of lectures:

1. Chemical bonds, proteins, saccharides, nucleic acids

2. Primary, secondary, tertiary and quarternary structure of proteins

3. Protein folding

4. Structure of nucleic acids, interaction motives of protein:nucleic acids complexes

5. Basic biophysical methods, methods of structure determination of macromolecules

6. Macromolecular crystallography

7. Structure of enzymes, drug design

8. Structure of viruses and viral proteins

9. Structure and function of membranes and membrane proteins

10. Structure and function of components of immune system

11. Large macromolecular complexes (respiration, transcription, translation)

Syllabus of tutorials:

Individual work covers composition of several protocols according to the manual and independent analysis of an actual structure biology paper.

Study Objective:

Goals of study are following: an independent analysis of a macromolecular structure, understanding of publications related to structures of macromolecules.

Study materials:

Compulsory literature:

C. Branden, J. Tooze, Introduction to Protein Structure 2nd Edition, Garland Science, New York, NY, 1999.

A. Liljas, L. Liljas, J. Piskur, G. Lindblom, P. Nissen, M. Kjeldgaard, Textbook of Structural Biology, World Scientific Publishing Co. Pte. Ltd., Singapore, 2009.

Optional literature:

B.Alberts, D. Bray, A. Johnson, J. Lewis, M. Raff, K Roberts, P. Walter, Základy buněčné biologie, Espero Publishing, s.r.o., Ústí nad Labem, 2005.

Z. Vodrážka, P. Rauch, J. Káš, Enzymologie, Vysoká škola chemicko-technologická, 1998.

Note:

Further information:

https://kiplwww.fjfi.cvut.cz/drupal7/?q=11SFBM

Time-table for winter semester 2024/2025:

	06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon
Tue
Wed
Thu
Fri	roomTR:386 Kovaľ T. 16:00–18:50 (lecture parallel1) Trojanova 13

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans:

• Fyzikální inženýrství - Inženýrství pevných látek (elective course)