Labelled Compounds

Course guarantor:

Stanislav Smrček

Lecturer:

Ján Kozempel, Stanislav Smrček

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

The lecture focuses on the preparation and separation of stable nuclides and radionuclides in the introductory part.

An overview of various labelling methods and the preparation of organic radiolabelled compounds is given.

Application of stable- and radio- labelled compounds in inorganic, organic chemistry, biochemistry and medicine

is discussed.

Particular attention is given to the theoretical aspects, such as isotope exchange and isotopic effects.

Requirements:

Syllabus of lectures:

1)Separation of natural nuclides and preparation of radionuclides.

2)Nomenclature of labelled compounds.

3)Preparation of organic compounds labelled with deuterium and tritium.

4)11C, 13C, and 14C labelled compounds.

5)Compounds of nitrogen - 15N.

6)Compounds of phosphorus - 32P.

7)Compounds of oxygen - 18O.

8)Compounds of sulphur - 35S.

9)Compounds of halogens.

10)Stability, analyses and purity of labelled compounds.

Syllabus of tutorials:

Study Objective:

The aim of this subject is to develop the knowledge in the field of preparation of labelled compounds and their use in various scientific research areas as well as in industry and other fields.

Study materials:

Basic:

1. L. Lešetický: Metody přípravy izotopicky značených sloučenin. Skripta UK v Praze, Přírodovědecká fakulta, SPN Praha 1977.

Recommended:

2. R.Voges, J.R. Heis, T. Moenius: Preparation of Compounds Labeled with tritium and carbon 14. Viley, Chichester, UK, 2009

Note:

Time-table for winter semester 2024/2025:

Time-table is not available yet

Time-table for summer semester 2024/2025:

Time-table is not available yet

The course is a part of the following study plans: