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Code Completion Credits Range
15TOX ZK 2 2+0
Martin Vlk, Ján Kozempel (guarantor)
Martin Vlk, Ján Kozempel (guarantor)
Department of Nuclear Chemistry

The lecture gives a comprehensive survey of toxicology of chemicals. It deals with general and special toxicology, legislation and work safety in chemical laboratory. Several selected chapters are devoted to analytical and predictive toxicology. General toxicology explains toxic indices, their determination and interpretation, hazard and risk, mechanisms of absorption, distribution, biotransformation and elimination of chemicals in a body, mechanisms of toxic effects and factors governing these effects. Physicochemical and biochemical interpretation of toxic actions is stressed.


The lecture is intended for students of all chemical branches. The basic knowledge of physico-chemical, organic, and inorganic chemistry and biochemistry is supposed. The exam is a test, to meet the requirement is more than 60% of the possible points.

Syllabus of lectures:

1. General toxicology ? basic nomeclature.

2. Biology, physiology; mechanisms of absorption and distribution of chemicals.

3. Biotransformation and elimination of chemicals.

4. Mechanisms of basic toxic effects; factors determining toxicity; toxicological indexes.

5. Experimental toxicology.

6. Qualitative and quantitative relationships between chemical structure and biological effects of chemicals.

7. Toxicology of inorganic compounds.

8. Toxicology of organic and organometallic compounds.

9. Analytical toxicology, ecotoxicology and prediction toxicology.

10. Legislation and interpretation of European law - REACH. 11. Safety work and hygiene in chemical laboratory

Syllabus of tutorials:
Study Objective:

The aim of lecture is to give connected survey of basic areas of toxicology. The lecture is opened by common toxicology, continued by special toxicology and chapters from special areas of toxicology close it.

Study materials:

Casaret & Doull?s Toxicology. The Basic Science of Poisons. 6th Ed. New York, McGrawHill 2001.

A Textbook of Modern Toxicology. 3rd Ed. Edited by Ernest Hodgson. New York, Wiley 2006.

Time-table for winter semester 2021/2022:
Time-table is not available yet
Time-table for summer semester 2021/2022:
Time-table is not available yet
The course is a part of the following study plans:
Data valid to 2022-08-12
For updated information see http://bilakniha.cvut.cz/en/predmet2783706.html