Radiopharmaceuticals 2

Garant předmětu:

Ján Kozempel

Lecturer:

Ján Kozempel, Marek Moša, Martin Vlk

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

The basic principles of nuclear chemistry. A survey of radionuclides used in nuclear medicine. The common methods of radiopharmaceuticals preparations. Quality and control of radiopharmaceuticals.The basic radiopharmaceuticals and their use in human diagnostic and therapy.

Requirements:

Knowledge of chemistry on the level of bachelor of chemistry and completed course of fundamentals of nuclear chemistry.

Syllabus of lectures:

1. Definition and clasification

2. Radionuclides, their selection and preparation

3. Chemical forms

4. Scintigraphic investigation in nuclear medicine

5. Instrumentation and pharmakology in nuclear medicine

6. Nuclear cardiology

7. Nuclear neurology

8. Nuclear nefrology

9. Nuclear oncology

10. Nuclear orthopedy, bone marrow and hematology in scint. picture

11. Other investigation methods in nuclear medicine

Syllabus of tutorials:

Study Objective:

The course provides the students with the knowledge of radionuclides used in nuclear medicine, common methods of radiopharmaceuticals preparations and quality and control of radiopharmaceuticals.

The students will acquire competence to work in the field of radiopharmacy.

Study materials:

Key literature:

1. Czech pharmacopoeia, latest update.

2. Kilbourne M.R.: Fluorine-18 Labelling of Radiopharmaceuticals. Nuclear Science Series, Natural Academy Press, Washington D.C., 1990.

3. Phelps M., Mazziotta J., Scelbert H.: Positron Emission Tomography and Autoradiography: Principles and Applications for Brain and Heart. Raven Press, New York, 1986.

4. Wolf A.P., Jones W.B.: Cyclotrones for biomedical radioisotope production.

Radiochim. Acta 34, 1 (1983).

Recommended literature:

1. Deckart H., Cox P.H.: Principles of Radiopharmacology. G. Fischer Verlag, Jena 1987.

2. Parker D.: Tumor Targeting with Radiolabelled Macrocycle-Antibody Conjugates.

Chem. Soc. Rev. 19, 271-291 (1990).

3. Schubiger P.A., Alberto R., Smith A.: Vehicles Chelators, and Radionuclides: Choosing the „Building Blocks“ of an Effective Therapeutic Radioimmunoconjugate

Note:

Time-table for winter semester 2023/2024:

Time-table is not available yet

Time-table for summer semester 2023/2024:

Time-table is not available yet

The course is a part of the following study plans:

• Jaderná chemie (elective course)
• Jaderná chemie (compulsory elective course)
• Radiolgická fyzika (elective course)