Disorders of Physiological Regulations

The course is not on the list Without time-table
Code Completion Credits Range Language
A6M33PFR KZ 2 2P+0C Czech
The course cannot be taken simultaneously with:
Pathological Physiology and Pathology (X33PAT)
The course is a substitute for:
Pathological Physiology and Pathology (X33PAT)
Garant předmětu:
Department of Cybernetics

The course builds on knowledge gained in the subject devoted to physiology and anatomy. It acquaints with selected disorders of physiological function of organ systems, adaptive body's response to the disorder and the course of pathogenesis of organ failure. Emphasis is placed on understanding the interdependence of physiological systems and understanding of the regulatory response for each organ disorders. For clearer explanation computer models, e-learning resources and wiki pages will be widely used.


Passing the exam in the subject of anatomy and physiology.

Syllabus of lectures:

1. Regulatory mechanisms of body fluid homeostasis and homeostasis of the cell populations. System view of the interdependence of physiological regulation.

2. Disorders of blood gases transport.

3. Disorders of acid-base and ion homeostasis of internal environment.

4. Disorders volume osmotic homeostasis of internal environment.

5. Disorders of the circulation system - left and right heart failure.

6. Cardiogenic, distribution, hypovolaemic and septic shock,impaired control of blood pressure.

7. Respiratory system disorders, disorders of ventilation, diffusion and perfusion.

8. Renal impairment, nephrotic syndrome, acute and chronic renal failure.

9. Disorders of gastrointestinal systems and liver.

10. Selected disorders of endocrine function. Diabetes. Pituitary disorders. Disorders of the adrenal gland. Disorders of thyroid gland.

11. Disorders of cell populations homeostasis, carcinogenesis.

12. Haematopoiesis disorders.

13. Immune disorders, inflammation.

14. Reserve.

For distance learning, e-learning system of 1st Medical Faculty, Charles University and MEFANET network (http://www.mefanet.cz) will be used. In addition to regular demonstrations of physiological systems failures in computer models each student receives individual given task,based on selected physiological subsystem available to get the computer model of this subsystem and additional literature. Its role will be to demonstrate the disorder using model and develop appropriate essay and presentation. Progress will be checked three times during the term. A necessary documentation should be submitted and the model demonstration should be presented to the fellow students. Exam grade will depend on activity points collected during the term as well as on the results of oral and written exams.

Syllabus of tutorials:
Study Objective:
Study materials:

[1] Silbernagl, S.; Despopoulos, A.: Color atlas of physiology, 2009,456 pp, ISBN 9783135450063 / [E_ISBN]

Georg Thieme Verlag.

[2] Sirbenagl, S.; Lang, F.: Color Atlas of Pathophysiology,2000, 406 pp, 180 illustrations, ISBN 9781604061444Georg Thieme Verlag.

[3] Silverthorn, D.E.: Human Physiology. An integrated Approach. Third Edition. Pearon Education Inc., publishing as Benjamin Cummings, San Francisco 2009, ISBN 0-321-55939-8, 912 stran.

[4] Keener, J.; Sneyd, J.: Mathematical Physiology. Springer, New York, Berlin, 1998, ISBN 0-387.98381

[5] Educational wiki-pages of the subject offering course learning material, presentation and links to electronic resources


Further information:
No time-table has been prepared for this course
The course is a part of the following study plans:
Data valid to 2023-09-24
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