Physiology and Pathophysiology of Cardiovascular System

Garant předmětu:

Ian Azarov

Přednášející:

Ian Azarov

Cvičící:

Ian Azarov, Ksenia Sedova

Předmět zajišťuje:

katedra biomedicínské techniky

Anotace:

The course provides with basic and applied information on the physiological processes in the cardiovascular system. It mostly concerns the questions how to assess different conditions of heart and circulation on the basis of instrumentally measured physiological variables (a diagnostic perspective). After completion, students will be able to analyze physiological parameters, such as ECG, arterial blood pressure, heart rate, etc; solve typical problems in the cardiovascular “domain”; and will learn conceptual approaches for the application of physiological knowledge in cardiology.

Požadavky:

In the case of foreign lecturers, there will be a weeklong block of intensive contact education for the number of students at least five. If the number of students is less than five, the course will be self-study with consultations using VoIP (e.g. Skype) and a contact 1-or 2-day seminar. The contact seminar will take place at the FBMI or at the home institution of a foreign lecturer. The subjects are concluded by an oral examination. The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study.

Two laboratory exercises are required for admission to the exam (attested by a protocol signed by the student, the tutor and the supervisor of the course).

The protocols will be archived in the Department for Doctoral Studies.

Osnova přednášek:

Lectures

1. Physiology of cardiac myocytes – ion channels and ionic currents, membrane potentials, contractile properties, cellular targets for heart diseases.

2. Generation of heart rhythm and activation spread – pacemakers, atrioventricular conduction, myocardial depolarization and repolarization, ECG.

3. Arrhythmogenesis – impulse generation abnormalities, conduction abnormalities, reentry.

4. The heart as a pump – cardiac cycle, cardiac output, arterial blood pressure, targets for autonomic regulation.

5. Circulation – systemic hemodynamics, control of local bloodflows and arterial blood pressure, hierarchy of circulation regulation.

6. Abnormal circulation, part 1 – hypotension and syncope, ischemia, circulatory shock.

7. Abnormal circulation, part 2 – essential arterial hypertension, pulmonary arterial hypertension.

8. Myocardial ischemia, part 1 – coronary circulation, oxygen demand and supply.

9. Myocardial ischemia, part 2 – atherosclerosis, stenosis, thrombosis, myocardial infarction.

10. Heart failure – cellular, organ and systemic mechanisms.

Osnova cvičení:

Exercises

1. Short- and long-term control of hemodynamics – cardiovascular parameters for evaluation of circulation.

2. Heart failure – cardiovascular parameters for evaluation of circulation.

Cíle studia:

The course provides with basic and applied information on the physiological processes in the cardiovascular system. It mostly concerns the questions how to assess different conditions of heart and circulation on the basis of instrumentally measured physiological variables (a diagnostic perspective). After completion, students will be able to analyze physiological parameters, such as ECG, arterial blood pressure, heart rate, etc; solve typical problems in the cardiovascular “domain”; and will learn conceptual approaches for the application of physiological knowledge in cardiology.

Studijní materiály:

Required:

[1] J.Hall. Guyton and Hall Textbook of Medical Physiology. 13th ed. Elsevier (2016);

[2] L.Lilly. Pathophysiology of Heart Disease. 6th ed. Wolters Kluwer (2016);

Recommended:

[1] J.Hall. Guyton and Hall Physiology Review. 3rd ed. Elsevier (2016);

[2] D.Zipes, P.Libby. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Elsevier (2019).

Poznámka:

Modul E

Rozvrh na zimní semestr 2023/2024:

Rozvrh není připraven

Rozvrh na letní semestr 2023/2024:

Rozvrh není připraven

Předmět je součástí následujících studijních plánů: