Organic chemistry 2

Vztahy:

In order to register for the course 15ORCA2, the student must have successfully completed or received credit for and not exhausted all examination dates for the course 15ORCA1. The course 15ORCA2 can be graded only after the course 15ORCA1 has been successfully completed.

In order to register for course 15POCHA, the student must have registered for course 15POCHA in a previous semester or in the same semester.

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

Introduction to the second group of organic compounds, carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals - industrial and natural. Introduction to the metods of structural analysis.

Requirements:

Syllabus of lectures:

1.Carboxylic acids – nomenclature, structure, properties, methods of preparation.

2.Carboxylic acids – reactivity. Dicarboxylic acids, methods of preparation, their reactions.

3.Substituted carboxylic acids – preparation, properties.

4.Halogen-, hydroxy-, oxo- and amino- acids – nomenclature, structure, preparation, reactivity.

5.Functional derivatives of carboxylic acids – nomenclature, structure, preparation, reactivity.

6.Esters – condensation reactions, use in syntheses.

7.Derivatives of carbonic acid, carbamates, nitriles, isonitriles, ketenes, isocyanates, carbodiimides.

8.Heterocyclic compounds – characterization, properties, preparation, reactivity.

9.Natural compounds – saccharides, terpenes, steroid hormones - nomenclature, structure, properties.

10.Natural compounds – lipids, alkaloids, secondary plant metabolites

11.Industrial organic compounds, tenzides, pesticides, pharmaceuticals.

12.Methods of structural analysis of organic compounds, basics of spectral methods.

Syllabus of tutorials:

1.Preparation and reactions of carboxylic acids.

2.Halogen-, hydroxy-, oxo-, amino- acids and their derivatives – nomenclature, properties, preparation and reactions.

3.Esters – preparation, reactions and use in organic synthesis.

4.Preparation and reactions of carbonic acid derivatives.

5.Preparation, reactions and properties of heterocyclic compounds.

6.Natural compounds – nomenclature, structure, occurrence, preparation and reactions, use.

7.Industrial organic compounds – types, use, preparation, specificity of reactions in laboratory and industrial scale.

8.Pharmaceuticals production – history, current demands, examples of syntheses, research and development of pharmaceuticals.

9.Basics of organic compounds structural analysis, spectral methods, principles of compounds identification.

10.Identification of simple organic compounds based on provided spectral data, NMR, MS, IR methods.

Study Objective:

The course of Organic chemistry 2, provides the students with the knowledge of the second group of organic compounds that include carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals, as well as introduction to the metods of structural analysis of organic compounds. The lecture extends the Organic chemistry 1 course.

The students will acquire competence to apprehend the advanced specialised organic chemistry courses.

Study materials:

Key Literature:

1.J. McMurry: Organic Chemistry, 9th Ed., Brooks/Cole Cengage Learning, 2015

2.F. A. Carey: Organic Chemistry, Mcgraw-Hill Education – Europe, 2016

Recommended Literature:

3.D. E. Lewis: Organic Chemistry – a Modern Perspective, Times Mirror Education Group, Inc. Dubunque, 1996

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Jaderná chemie (compulsory course in the program)