Organic chemistry 2

Relations:

In order to register for the course 15ORCA2, the student must have successfully completed or received credit for and not exhausted all examination dates for the course 15ORCA1. The course 15ORCA2 can be graded only after the course 15ORCA1 has been successfully completed.

In order to register for course 15POCHA, the student must have registered for course 15POCHA in a previous semester or in the same semester.

Course guarantor:

Ján Kozempel

Lecturer:

Ján Kozempel, Stanislav Smrček, Martin Vlk

Tutor:

Ján Kozempel, Michal Sakmár, Stanislav Smrček, Martin Vlk

Supervisor:

Department of Nuclear Chemistry

Synopsis:

Introduction to the second group of organic compounds, carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals - industrial and natural. Introduction to the metods of structural analysis.

Requirements:

Requirements for successful completion of the course (exam credit):

Minimum 60% success rate in the exam test (possibility to earn additional points from homework and participation in exercises)

Attendance in exercises at least 70%

Syllabus of lectures:

1.Carboxylic acids nomenclature, structure, properties, methods of preparation.

2.Carboxylic acids reactivity. Dicarboxylic acids, methods of preparation, their reactions.

3.Substituted carboxylic acids preparation, properties.

4.Halogen-, hydroxy-, oxo- and amino- acids nomenclature, structure, preparation, reactivity.

5.Functional derivatives of carboxylic acids nomenclature, structure, preparation, reactivity.

6.Esters condensation reactions, use in syntheses.

7.Derivatives of carbonic acid, carbamates, nitriles, isonitriles, ketenes, isocyanates, carbodiimides.

8.Heterocyclic compounds characterization, properties, preparation, reactivity.

9.Natural compounds saccharides, terpenes, steroid hormones - nomenclature, structure, properties.

10.Natural compounds lipids, alkaloids, secondary plant metabolites

11.Industrial organic compounds, tenzides, pesticides, pharmaceuticals.

12.Methods of structural analysis of organic compounds, basics of spectral methods.

Syllabus of tutorials:

1.Preparation and reactions of carboxylic acids.

2.Halogen-, hydroxy-, oxo-, amino- acids and their derivatives nomenclature, properties, preparation and reactions.

3.Esters preparation, reactions and use in organic synthesis.

4.Preparation and reactions of carbonic acid derivatives.

5.Preparation, reactions and properties of heterocyclic compounds.

6.Natural compounds nomenclature, structure, occurrence, preparation and reactions, use.

7.Industrial organic compounds types, use, preparation, specificity of reactions in laboratory and industrial scale.

8.Pharmaceuticals production history, current demands, examples of syntheses, research and development of pharmaceuticals.

9.Basics of organic compounds structural analysis, spectral methods, principles of compounds identification.

10.Identification of simple organic compounds based on provided spectral data, NMR, MS, IR methods.

Study Objective:

The course of Organic chemistry 2, provides the students with the knowledge of the second group of organic compounds that include carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals, as well as introduction to the metods of structural analysis of organic compounds. The lecture extends the Organic chemistry 1 course.

The students will acquire competence to apprehend the advanced specialised organic chemistry courses.

Study materials:

Key Literature:

1.J. McMurry: Organic Chemistry, 9th Ed., Brooks/Cole Cengage Learning, 2015

2.F. A. Carey: Organic Chemistry, Mcgraw-Hill Education Europe, 2016

Recommended Literature:

3.D. E. Lewis: Organic Chemistry a Modern Perspective, Times Mirror Education Group, Inc. Dubunque, 1996

Note:

Time-table for winter semester 2025/2026:

Time-table is not available yet

Time-table for summer semester 2025/2026:

Time-table is not available yet

The course is a part of the following study plans:

• Jaderná chemie (compulsory course in the program)