Basics of Oncology

Course guarantor:

Lecturer:

Tutor:

Supervisor:

Department of Dosimetry and Application of Ionizing Radiation

Synopsis:

1.Basics of cell biology and human anatomy

2.Cell differentiation and introduction to epigenetics

3.DNA damage and mutagenesis overview of the best known mutations - BRCA1/2, TP53, RAS

4.From mutation to tumorigenesis proto-oncogenes, oncogenes, anti-oncogenes

5.Tumour microenvironment - hypoxia, angiogenesis a necrosis

6.Cancer stem cells, circulating tumour cells and metastatic behaviour of tumours

7.Tumour types and their classification (TNM, Gleason)

8.Tumour histology, biopsies, tumour markers

9.Diagnostics an overview of best known methods

10.Cancer treatment and its success rate

Requirements:

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Syllabus of lectures:

1.Basics of cell biology and human anatomy

2.Cell differentiation and introduction to epigenetics

3.DNA damage and mutagenesis overview of the best known mutations - BRCA1/2, TP53, RAS

4.From mutation to tumorigenesis proto-oncogenes, oncogenes, anti-oncogenes

5.Tumour microenvironment - hypoxia, angiogenesis a necrosis

6.Cancer stem cells, circulating tumour cells and metastatic behaviour of tumours

7.Tumour types and their classification (TNM, Gleason)

8.Tumour histology, biopsies, tumour markers

9.Diagnostics an overview of best known methods

10.Cancer treatment and its success rate

Syllabus of tutorials:

Study Objective:

Knowledge:

Knowledge about DNA damage and mutagenesis that leads to tumorigenesis. General information about tumours and their microenvironment. Overview of diagnostic and therapeutic methods used in oncology.

Abilities:

General knowledge about oncology.

Study materials:

Key references:

[1]ALBERTS, Bruce. Essential cell biology. 4th ed. New York: Garland Science, c2014. ISBN 978-0-8153-4454-4.

[2]WEINBERG, Robert A. The biology of cancer. 2nd ed. New York: Garland Science, c2014. ISBN 978-0-8153-4528-2.

Recommended references:

[3]HAYAT, M. A., ed. Methods of Cancer Diagnosis, Therapy, and Prognosis [online]. Dordrecht: Springer Netherlands, 2010 [cit. 2020-02-05]. DOI: 10.1007/978-90-481-3186-0. ISBN 978-90-481-3185-3.

[4]VERMA, Mukesh, ed. Cancer Epidemiology [online]. Totowa, NJ: Humana Press, 2009 [cit. 2020-02-05]. Methods in Molecular Biology. DOI: 10.1007/978-1-59745-416-2. ISBN 978-1-58829-987-1.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Jaderné inženýrství - Aplikovaná fyzika ionizujícího záření (elective course)
• Radiologická technika (elective course)