Basics of Oncology

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Dosimetry and Application of Ionizing Radiation

Synopsis:

1.Basics of cell biology and human anatomy

2.Cell differentiation and introduction to epigenetics

3.DNA damage and mutagenesis – overview of the best known mutations - BRCA1/2, TP53, RAS

4.From mutation to tumorigenesis – proto-oncogenes, oncogenes, anti-oncogenes

5.Tumour microenvironment - hypoxia, angiogenesis a necrosis

6.Cancer stem cells, circulating tumour cells and metastatic behaviour of tumours

7.Tumour types and their classification (TNM, Gleason)

8.Tumour histology, biopsies, tumour markers

9.Diagnostics – an overview of best known methods

10.Cancer treatment and its success rate

Requirements:

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Syllabus of lectures:

1.Basics of cell biology and human anatomy

2.Cell differentiation and introduction to epigenetics

3.DNA damage and mutagenesis – overview of the best known mutations - BRCA1/2, TP53, RAS

4.From mutation to tumorigenesis – proto-oncogenes, oncogenes, anti-oncogenes

5.Tumour microenvironment - hypoxia, angiogenesis a necrosis

6.Cancer stem cells, circulating tumour cells and metastatic behaviour of tumours

7.Tumour types and their classification (TNM, Gleason)

8.Tumour histology, biopsies, tumour markers

9.Diagnostics – an overview of best known methods

10.Cancer treatment and its success rate

Syllabus of tutorials:

Study Objective:

Knowledge:

Knowledge about DNA damage and mutagenesis that leads to tumorigenesis. General information about tumours and their microenvironment. Overview of diagnostic and therapeutic methods used in oncology.

Abilities:

General knowledge about oncology.

Study materials:

Key references:

[1]ALBERTS, Bruce. Essential cell biology. 4th ed. New York: Garland Science, c2014. ISBN 978-0-8153-4454-4.

[2]WEINBERG, Robert A. The biology of cancer. 2nd ed. New York: Garland Science, c2014. ISBN 978-0-8153-4528-2.

Recommended references:

[3]HAYAT, M. A., ed. Methods of Cancer Diagnosis, Therapy, and Prognosis [online]. Dordrecht: Springer Netherlands, 2010 [cit. 2020-02-05]. DOI: 10.1007/978-90-481-3186-0. ISBN 978-90-481-3185-3.

[4]VERMA, Mukesh, ed. Cancer Epidemiology [online]. Totowa, NJ: Humana Press, 2009 [cit. 2020-02-05]. Methods in Molecular Biology. DOI: 10.1007/978-1-59745-416-2. ISBN 978-1-58829-987-1.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Jaderné inženýrství - Aplikovaná fyzika ionizujícího záření (elective course)
• Radiologická technika (elective course)