Nanotechnology for Medicine

Course guarantor:

Lecturer:

Tutor:

Supervisor:

Department of Biomedical Technology

Synopsis:

The course introduces students to nanomaterials that can be used in modern analytical and diagnostic methods in nanomedicine. The course lectures focus on nanoparticles, their basic characteristics such as size and chemical potential, their preparation methods and surface functionalization. The course also covers the optical characteristics of nanomaterials and the basics of luminescence and phosphorescence principles and their detection using confocal principles. In the last part of the course, magnetic properties of nanoparticles and nano-NMR detection methods are presented and examples used for optical and magnetic methods in nanomedicine for detection of targeted nanoparticles.

Requirements:

Requirements for credit: 80% attendance at the exercises, passing the final test at a minimum of 50%.

Assessment of the exam: the exam will be given in the form of a test with questions to be answered by the students. Some questions may carry more weight in the assessment than others, for example those involving a numerical problem or requiring a complex approach to solving. After successful completion of the written test, oral retesting for a better grade is possible. The grade will correspond to the pass percentage exactly according to the ECTS grading scale in force.

Syllabus of lectures:

Introduction to nanotechnology. Classification and characteristics of nanomaterials

Nanoparticles, preparation, nanodiamond, risks of nanoparticles

Basic methods of measuring nanoparticle properties, AFM, Z-potential

Functionalisation and targeting of nanoparticles

Luminescence and phosphorescence of nanoparticles

Single photon sources,

Confocal microscopy methods

Principles of STED imaging

Principle of NMR methods at nanoscale

Optical, and acoustic detection of nanoparticles in cells

Magnetic detection of nanoparticles in cells

Application of selected nanoparticles for medical diagnostics

Syllabus of tutorials:

Derivation of the relation for the scattering of the world by nanoparticles

Derivation of light absorption and reflection in nanoparticles

Autocorrelation function, examples

Derivation of the particle size relationship using the DLS method

Mathematical description of Z-potential, description of electrochemical equilibrium

2-level system, derivation of Einstein relations for luminescence

Derivation of confocal microscope resolution

Derivation of the resolution of the STED method

Autocorrelation function for single photon description

Proton resonance, examples

Calculation of proton resonance frequency

Determination of nano NMR sensitivity

Study Objective:

Study materials:

Mandatory:

Nanomaterial Characterization: An Introduction, Wiley, ed. Ratna Tantra ISBN: 978-1-118-75359-0 May 2016.

Confocal Microscopy for Biologists, Publisher Springer Science+Business Media, Imprint Kluwer Academic/Plenum Publishers, Publication City/Country New York, NY, United States, ISBN10 0306484684, ISBN13 9780306484681.

Recomanded::

Atomic Force Microscopy: Understanding Basic Modes and Advanced Applications, Greg Haugstad. Print ISBN:9780470638828 |Online ISBN:9781118360668 |DOI:10.1002/9781118360668, Copyright © 2012 John Wiley & Sons, Inc.

Micro and Nano Scale NMR: Technologies and Systems, Jens Anders (EditorWIley, ISBN: 978-3-527-34056-9 May 2018

G. Oberdorster, aj., Nanotoxycology: An emerging discipline evolving from studies of ultrafine particles,Environmental Health Perspectives, 2005, 113(7), s. 823-839.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Biomedical Engineering (compulsory course)