Biotransport

Course guarantor:

Pavel Kučera

Lecturer:

Pavel Kučera, Roman Matějka, Jana Matějková

Tutor:

Ladislav Bís, Roman Matějka, Jana Matějková, Leoš Tejkl

Supervisor:

Department of Biomedical Technology

Synopsis:

Basic concepts of a systemic approach to the human body.

Functional organization of living organisms. Integrated functions and importance of systems providing applications for biomedical technicians and engineers.

Principles of experimental and examination methods used in physiology and medicine.

Examples of application of modern technologies in medicine.

Requirements:

STUDENT IS OBLIGATED TO GO FOR EXERCISE READY! OTHERWISE, IT WILL BE EXCLUDED FROM THE EXERCISE

Credit conditions: Participation in exercises without absence, all absences must be replaced.

From the practical exercises, it is possible to prepare and submit a report within 14 days, which will be scored. Protocols must be submitted electronically via moodle. Protocols are scored, the influence of points on the final evaluation is 35%.

If the student does not submit the report in time but participated in the task, he is entitled to credit with 0 points for the task.

Exam conditions: The exam is in the form of a test with computational examples, lasts 3 hours, and consists of 12-15 questions. It is possible to participate only with the credit granted, ie participation in the exercises was 100%, or all absences were replaced.

Syllabus of lectures:

1 SYSTEMIC APPROACH TO THE HUMAN ORGANISM

Functional organization of living systems : what is life; thermodynamics of living

systems; evolutionary and ecological aspects.

Biological transports : principles and classification; bioenergy.

From the cell to the organism : functional hierarchy and coordination subsystem é mU human

organism ; e experimental approach and modeling.

Adaptation : physical and chemical parameters compatible with survival; concept

homeostasis.

2 EXCHANGES - THE BASIS OF LIFE

C irkulace blood and gas exchange . Functional dependencies and regulatory mechanisms.

Ischemia, hypoxia, ox and dation stress. Technological support.

Assimilation and excretion . Motility of the digestive system (special topic: from the idea

for clinical use). Renal mechanisms of substance and electrolyte transport;

dialysis.

Communication . Principles of intercellular communication. Nerve signals (origin,

propagation, coding, storage, plasticity ). Neuromuscular system: from motor

units to talk.

3 INTEGRATION MECHANISMS

Homeostasis of vital parameters.

Adaptation to physical exertion.

Behavior: introduction to cognitive functions. Man - zoon politician.

Syllabus of tutorials:

The internship will take place in four-hour blocks every two weeks. In each block, tasks will be discussed according to the schedule.

Tasks:

1. Hemolysis - spectrophotometry

2. Ergospirometry - a measurement of oxygen consumption

3. Electromyography - excitability

4. Determination of creatinine in urine

5. + 6. + 7. Tissue engineering

Study Objective:

- To revise physiological s knowledge and from the perspective of an engineer.

- Understand the principles of experimental and investigative methods used in physiology and medicine.

- Gain a solid overview of the integration of functional systems with the application for

technological development. - Stimulate the search for open problems and their solutions.

Study materials:

Required :

[1] P. Kucera: Documents and outlines distributed in advance to lectures.

[2] Lauralee Sherwood: Human physiology, From cells to Systems, 9th edition, 2016. Free Download (Academia.edu)

Recommended :

[3] W. Boron, EL Boulpaep Medical Physiology, 3rd edition, Elsevier 2016.

[4] AC Guyton, JE Hall Textbook of Medical Physiology, 13th edition, Elsevier 2015 .

Note:

Further information:

https://moodle-vyuka.cvut.cz/course/view.php?id=12279

Time-table for winter semester 2025/2026:

	06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon
Tue	roomKL:B-137 Kučera P. Matějka R. 08:00–09:50 (lecture parallel1) Kladno FBMI
Wed
Thu
Fri	roomKL:A-110 Matějková J. 08:00–19:50 ODD WEEK (lecture parallel1) Kladno FBMI roomKL:B-121 Matějková J. 08:00–19:50 ODD WEEK (lecture parallel1) Kladno FBMI roomKL:A-110 Matějková J. 08:00–19:50 EVEN WEEK (lecture parallel1) Kladno FBMI roomKL:B-121 Matějková J. 08:00–19:50 EVEN WEEK (lecture parallel1) Kladno FBMI roomKL:A-110 Matějková J. 08:00–19:50 EVEN WEEK (lecture parallel1) Kladno FBMI roomKL:B-121 Matějková J. 08:00–19:50 EVEN WEEK (lecture parallel1) Kladno FBMI

Time-table for summer semester 2025/2026:

Time-table is not available yet

The course is a part of the following study plans:

• Biomedical Engineering (compulsory course)