Biological Effects of Ionizing Radiation

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Health Care Disciplines and Population Protection

Synopsis:

The lectures will give an overview of basic radiation biology. Students will become familiar with the biological effects of ionizing radiation: the physical and chemical processes by which radiation causes damage to the biological material; mechanisms of radiation action on the DNA and other constituents of the cell; types of damage and their repair; subcellular and cellular sensitivity and radiation response; physical, chemical and biological modifiers of radiation action; theories and models of cellular survival; and radiation biology of normal and neoplastic tissues.

Requirements:

classified credit:

demonstration of the knowledge mastered by a written 2 tests, always 50 % success rate.

Oral examination on the basis of the decision field supervisor.

note: the interval between testing and the outcome in due time or the corrective terms must be at least seven days.

Syllabus of lectures:

1st Week - Introduction

2nd week - Atomic structure. Radioactivity

3rd week - Types and properties of ionizing radiation. Sources of ionizing radiation. Interaction of ionizing radiation with matter

4th Week - Radiation protection. Radioprotection

5th Week - TEST 1

6th Week - Interaction of ionizing radiation with tissue

7th week - DNA damage repair, DNA damage and cell cycle

8th Week - Deterministic and stochastic effects

9th Week - Use of ionizing radiation in medicine

10th Week - Radiation accidents

11th Week - Excursion

12th week - Excursion

13th Week - Consultation

14th week - TEST 2

Note - The order of presentations may change, students will be informed.

Syllabus of tutorials:

N/A

Study Objective:

Ionizing radiation. Non-ionizing radiation. Interaction of ionizing radiation with tissue. Deterministic and stochastic effects. DNA damage repair, DNA damage and cell cycle. Basics of radiation protection.

Study materials:

1. HALL, Eric J. a Amato J. GIACCIA. Radiobiology for the radiologist. 7th ed. Philadelphia: Wolters Kluwer :Lippincott Williams & Wilkins, 2012.

2. STEEL, G. Gordon., ed. Basic clinical radiobiology. 3rd ed. London: Arnold, 2002.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Optics and Optometry - full-time (compulsory elective course)