Immunochemistry

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

The series of lectures ?Glycoconjugate and Immunochemistry? include the actual knowledge in the field of glycoproteins, glycolipids, proteoglycans and other glycoconjugates and their biological and biochemical aspects, biosynthesis, and roles in different diseases. Methods for detection and characterization of glycoproteins and glycopeptides are discussed as well. The second part of the lectures is focused on basic immunochemistry including description of basic terms of immunology, function of immune system and its role in diseases. Basic methods used in immunology are also summarized.

Requirements:

For easy understanding of lectures, basic knowledge of chemistry and biochemistry at bachelor level is required.

Syllabus of lectures:

1)Introduction to glycoconjugates, historical background, saccharides and their structure, chemical reactions of glycans.

2)N-glycans and O-glycans (biosynthesis, functions, structure).

3)Other glycoconjugates (glycosphingolipids, GPI, hyaluronan, proteoglycans, glycosaminoglycans).

4)Glycoproteins in different organisms.

5)Lectins.

6)Glycoconjugates and diseases.

7)Analytical methods for detection and characterization of glycoproteins.

8)Immunochemistry, historical overview and basic terms.

9)Immunity system and its compartments.

10)Immunity system in diseases.

11)Methods in imunology.

Syllabus of tutorials:

Study Objective:

The aim of the course is to provide present knowledge in the field of glycoproteins and other glycoconjugates, inform students about the biological and biochemical properties of glycoconjugates and its usage. Students will be further informing about basic knowledge in the field of immunochemistry, its usage including modern methods in clinical praxis.

Study materials:

Recommended references:

[1] A. Varki et al.: Essentials of Glycobiology, 2nd edition, Cold Spring Harbor (NY), 2009 (http://www.ncbi.nlm.nih.gov/books/NBK1908/).

[2] V. Hořejší, J. Bartůňková: Základy imunologie, 2. vydání, Triton, 2001.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: