Fundamentals of Medical Chemistry and Biochemistry

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Health Care Disciplines and Population Protection

Synopsis:

The course focuses on acquainting students with the basics of chemistry and biochemistry to clarify the chemical structure, properties and reactions of substances that form the basis of living organisms. It is focused on the principles of textile and energy transformations in organisms. The goal is to learn the basics of Medical Chemistry and Biochemistry and descriptive understanding of autonomous and coupled metabolic processes associated with exchange of materials and energy gain and subject to regulatory ovlivňování.seminářích.

Requirements:

The graded credit is required 90% attendance at seminars. Another condition is the processing of paper on a given topic, including presentations and pass a written test with answers elected during the credit period.

Syllabus of lectures:

Importance of biochemistry in medical fields (the definition of biochemical fields - Pathobiochemistry, Clinical Biochemistry), biochemistry of the cell (cellular organelles, cell membrane - membrane transport).

The composition of living organisms (biogenic elements - makrobiogenní, mikrobiogenní, basic organic compounds of living matter - nucleic acids, proteins, carbohydrates, lipids).

Xenobiochemistry (classification of toxic substances, factors influencing toxic effect toxikinetika, the mechanism of toxic effect, clinical manifestations of intoxication).

General principles of metabolism (metabolic events, Krebs cycle), differences in metabolism between organisms and their importance; Hereditary metabolic disorders.

Enzymes (enzyme molecule structure, principles of action, the names of enzymes, enzyme utilization in diagnosis).

Water and minerals (water distribution, major ions, water loss), Acid-Base Balance and its disorders.

Vitamins and hormones, free radicals and antioxidants.

Atherosclerosis, risk factors, diabetes mellitus.

Properties of laboratory methods (analytical, clinical, screening); reference values??.

Note - the order of lectures may change, students will be informed of the change.

Syllabus of tutorials:

Role of elements in the body

Chemical composition of cells

Structure and carbohydrate metabolism

Structure and metabolism of lipids

Structure and function of amino acids

Structure and function of nucleotides

Hormonal regulation of biochemical processes

Biochemistry of kidney

Biochemistry bones

Biochemistry of liver

Biochemistry heart

lung biochemistry

blood Biochemistry

Biochemistry of nervous tissue

Chemistry of immune responses

The issue of free radicals and antioxidants in medicine

Biochemistry of nutrition and starvation

Study Objective:

The goal is to give students a basic overview of the structure and function of cellular compartments.

In lectures, it is also dealt with a range of issues dealing with the biochemistry of organ systems and metabolism of body fluids, electrolytes and acid-base balance.

Study materials:

[1]Habermann, V.: Lékařská chemie. Praha: Karolinum, 2004, ISBN 80-246-0789-1.

[2]Bruce, A., et al.: Základy buněčné biologie: úvod do molekulární biologie buňky. Ústí nad Labem: Espero, 2006, ISBN 80-902906-2-0.

[3]Trojan, S., et al.: Lékařská fyziologie, Praga: Grada, 2003, ISBN 80-247-0512-5.

[4]Řezáčová, M., Stoklasová, A.: Základy biochemie lidského organismu, Praha: Karolinum, 2008, ISBN 978-80-246-1510-3.

[5]Patočka, J.: Úvod do obecné toxikologie. Praha: Manus, 2003. ISBN 80-86571-04-1.

[6]Racek, J. a kol.: Klinická biochemie. 2. vydání, Praha: Galén, Karolinum, 2006. ISBN 80-7262-324-9

[7]Štern, P. a kol.: Obecná a klinická biochemie. Karolinum: Praha 2005. ISBN 80-246-1025-6

[8]Kodíček, M.: Biochemické pojmy - výkladový slovník, verze 2.0 [online]. VŠCHT v Praze: 2007. Dostupné online (http://vydavatelstvi.vscht.cz/knihy/uid_es-002/). ISBN 978-80-7080-669-2.

[9]Sofková, D., a kol.: Biochemie - základní kurz. Karolinum: Praha 2005. ISBN 80-7184-936-7

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: