Materials for Application in Biomedicine
- Garant předmětu:
- Department of Materials Engineering
Generalized considerations: biocompatibility - definitions and issues. Introduction to the biological environment. Material response: function and degradation of materials in vitro and in vivo. Mechanics of materials: deformation and failure. Swelling and leaching of plastics; corrosion and dissolution of metals. Tribology of biomaterials: friction and wear. Properties of implant materials. Host response: reaction of biological molecules with biomaterial surfaces. Biological effects of implants. The inflamatory process; coagulation and hemolysis; alergic foreign-body response, chemical and foreign body carcinogenesis; adaptation. Implant materials: clinical performance. Methods of tests for biological performance. In vitro test methods. In vivo implant models. Qualification of implant materials. Standardization and regulation of implant materials. Design and selection of implant materials.
- Syllabus of lectures:
1.Biocompatibility - definitions and issues. Introduction to the biological environment.
2.Mechanics of biomaterials: deformation and failure (metals, ceramics, plastics, carbon, composites)
3.Methods of measurement of structure and composition of materials
4.Properties of biomaterials? surfaces (topographical, tribological, chemical)
5.Functional properties of biomaterials; degradation, swelling and leaching of plastics; corrosion and dissolution of metals.
6.Surface engineering for biomaterials - surface modifications and films
7.Imunity system. The inflamatory process; coagulation and hemolysis; alergic foreign-body response, chemical and foreign body carcinogenesis; adaptation.
8. Methods of biocompatibility tests, tests for biological performance. In vitro and in vivo implant models; sterilisation.
9.Properties of implant materials surface. Host response: reaction of biological molecules and living cells with biomaterial surfaces.
10.Qualification of implant materials. Standardisation and regulation of implant materials.
11.Design and selection of implant materials - stem of total hip implant (composite PEEK+C fibres), heart valves and heart pump (TiN layer), TiNi with plasma sprayed layer
12.Database systems (COMPENDEX, MEDLINE, WOS, PLATAN, etc.)
- Syllabus of tutorials:
Introduction of demands on biomaterials (i.e. materials for biomedical applications), engineering and physical, chemical and biological aspects of live tissues and organisms in contact with a surface of the material.
- Study Objective:
- Study materials:
1. Filip P., Progresivní typy biomateriálů, Skripta, VŠB-TU Ostrava 1995.
2. Valenta J. a kol. Biomechanika, kap. 3 (Beznoska S., Löbl K.), Akademia, Praha 1985.
3. Beznoska S., Umělé náhrady lidských kloubů, SNTL, Praha 1987.
4. Koutský J., Biomateriály, Skripta, ZčU Plzeň 1997.
5. Dee K.C., Puleo D.A., Bizios R.: An introduction to tissue-biomaterial interactions,Willey&Sons, Hoboken, N.J. 2003.
6. Valenta J. et al, Biomechanics, Chapter 3 (Beznoska S., Löbl K.), Academia, Praha 1993.
7. Wintermantel E., Ha S.-W., Biokompatible Werkstoffe und Bauweisen, Springer, Berlin 1996.
8. Black J., Biological Performance of Materials, Marcel Dekker, New York 1992.
9. Silver F.H., Biomaterials, medical devices and tissue engineering, Chapman&Hall, London 1993.
- Further information:
- No time-table has been prepared for this course
- The course is a part of the following study plans: