Biomechanics of hard tissues

Course guarantor:

Lecturer:

Tutor:

Supervisor:

Department of Mechanics, Biomechanics and Mechatronics

Synopsis:

Bone morphology and functions (mechanical and physiological) - support, lever system, protection, hematopoiesis, mineral homeostasis. Histology - microscopic structures of bone types (cortical and cancellous bone), skeletal processes (osteoblasts, osteocytes, osteoclasts), Haversian system. Physical properties - bone structure and mechanical properties of cortical bone (experimental technique, strength, hardness, anisotropy, cyclic fatigue, relaxation, limit analysis, influence of bone osteogenesis and aging). Piezo-electric and electro-kinetic phenomena. Osteo-dysplasia. Cortical bone remodelling (control parameters, proliferation, bone surface). Biomechanics of trabecular bone (morphology, strength, moduli, density) Trabecular bone remodelling (numerical model, remodelling of the human vertebra spongiosis, atrophy simulation). Osteoporosis. Geometrical and mechanical properties of animal long bones.

Requirements:

Statics, Kinematics, Strength of Materials, FEM, Biomechanics, Anatomy

Syllabus of lectures:

1.Bone morphology and functions (mechanical and physiological).

2.Physical properties - bone structure and mechanical properties of cortical bone

3.Experimental technique, strength, hardness, anisotropy.

4.Cyclic fatigue, relaxation, limit analysis, influence of bone osteogenesis and bone aging.

5.Piezo-electric and electro-kinetic phenomena

6.Osteo-dysplasia. Cortical bone remodelling (control parameters, proliferation, bone surface).

7.Biomechanics of trabecular bone (morphology, strength, moduli, density)

8.Trabecular bone remodelling (numerical model, remodelling of the human vertebra spongiosis, atrophy simulation). Osteoporosis.

9.Geometrical and mechanical properties of animal long bones.

10.Clinical application of bone biomechanics

Syllabus of tutorials:

Biomechanics of hard tissues, creation of mathematical models, experimental assessment of biomechanical characteristics

Study Objective:

Study materials:

Základní:

S.C. Cowin (2001) Bone Mechanics Handbook, Second Edition. CRC Press, ISBN: 9780849391170.

J.D. Currey (2006) Bones: Structure and Mechanics, Princeton University Press, ISBN: 9780691128047

Doporučená:

X.Wang, J.S. Nyman, M. Reyes, X. Dong (2010) Fundamental Biomechanics in Bone Tissue Engineering (Synthesis Lectures on Tissue Engineering) Morgan and Claypool

Publishers, ISBN: 1608451690

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: