Biological Effects of Ionizing Radiation

Lecturer:

Marián Liberko, Jozef Rosina, Jozef Sabol

Tutor:

Marián Liberko

Supervisor:

Department of medical branches and humanities

Synopsis:

The lectures will give an overview of basic radiation biology. Students will become familiar with the biological effects of ionizing radiation: the physical and chemical processes by which radiation causes damage to the biological material; mechanisms of radiation action on the DNA and other constituents of the cell; types of damage and their repair; subcellular and cellular sensitivity and radiation response; physical, chemical and biological modifiers of radiation action; theories and models of cellular survival; and radiation biology of normal and neoplastic tissues.

Requirements:

classified credit:

demonstration of the knowledge mastered by a written test, 80 % success rate.

Oral examination on the basis of the decision field supervisor.

note: the interval between testing and the outcome in due time or the corrective terms must be at least seven days.

Syllabus of lectures:

1st Week - Construction of a cell. DNA. Cell cycle.

2nd week - DNA repair processes. Chromosomal aberrations.

3rd week - Radiobiology definitions and units of physical processes occurring in the absorption of radiation, absorption mechanisms, methods of radiation detection.

4th Week - Dosimetry.

5th Week - Effects of ionizing radiation on the level of cells and tissues.

6th Week - Biodozimetrie.

7th week - The clinical radiobiology. Effects of radiation on the embryo and fetus, hereditary effects, late effects of ionizing radiation.

8th Week - Acute and chronic radiation sickness.

9th Week - Radiomodulátory. Interaction of radiation with chemicals.

10th Week - Introduction to radiation protection.

11th Week - Nuclear Energy.

12th week - Terrorism, the possibility of misuse of nuclear weapons

13th Week - Introduction to radiotherapy.

14th week - Free topic

Note - The order of presentations may change, students will be informed.

Syllabus of tutorials:

N/A

Study Objective:

12th week - terrorism, the possibility of misuse of nuclear weaponsf cell, tissue, full body. Fundamentals of pathology and diagnosis of radiation sickness, pre-medical assistance.Basics of radiation protection. Non-ionizing radiation.

Study materials:

Kuna, P. a kol.: Vojenská radiobiologie. VLA JEP, Hradec Králové 1991

Navrátil, L., Rosina, J. a kol.: Lékařská biofyzika. Grada, Praha 2005

Additional recommended literature

Butomo, N.V., Grebenjuk, A.N., Legeza, V.I. a kol.: Osnovy medicinskoj radiobiologii. Foliant, Sankt Peterburg 2004

Hall, E.J.: Radiobiology for the Radiologist. Lippincott, Philadelphia 2000

Steel, G.G.: Basic Clinical Radiobiology. Edward Arnold, London 1993

Note:

Time-table for winter semester 2011/2012:

Time-table is not available yet

Time-table for summer semester 2011/2012:

	06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon
Tue
Fri
Thu	roomKL:C-4 Liberko M. Sabol J. 08:00–09:50 (lecture parallel1) Kladno FBMI Malý sál
Fri

The course is a part of the following study plans:

• Bakalářský studijní obor Biomedicínský technik - prezenční (compulsory elective course)