Radiation Methods in Biology and Medicine

Lecturer:

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

In the first part, the sources of ionizing radiation (IR) used in biology and medicine are thoroughly discussed. Description of interaction of IR with matter and influence of ionizing radiation on biologically important structures and organisms follows. The last part of the course is dedicated to theory of radiobiological action, radiodiagnostic and radiotherapeutical methods, safeguard and dozimetry.

Requirements:

fundamentals of physical and radiation chemistry

Syllabus of lectures:

1.Description and comparison of irradiation sources utilized in radiation biological and radiation medicinal applications.

2.Radiolysis of water and selected inorganic compounds in water solutions.

3.Structural units of living organisms.

4.Influence of ionizing radiaton on glycides, lipides, amino acids, proteins, vitamins, ferments, hormones, nucleic acids.

5.Characterization of biological effects of individual types of ionizing radiation.

6.Effects of irradiation on chemical processes in living organisms.

7.Theory of radiobiological action, reparation processes.

8.Effect of irradiation on cells of simple and complex organisms, mutual comparison.

9.Effects of irradiation on humans, radiotherapeutical methods.

10.Imaging and radiodiagnostic methods.

11.Overview of basic calculations in radiation medicine and biology.

12.Safeguard, dozimetric measuements.

Syllabus of tutorials:

Study Objective:

Getting knowledge on application of ionizing radiation in biological and medical science and research. Ability to apply obtained knowledge in practical aplications and calculations.

Study materials:

Key references:

Voet D, Voet J.G.: Biochemistry, John Wiley and Sons, 1990

Recommended references:

Scharf, W.H.: Biomedical particle accelerators, AIP Press, New York 1994.

Farhataziz, Rodgers, M. A. J., editoři: Radiation chemistry - Principles and applications, VCH Publishers, Inc., New York, 1987.

Arena, V.: Ionizing radiation and life: an introduction to radiation biology and biological radiotracer methods. Mosby, Saint Louis, 1971.

Bednář, J.: Theoretical foundations of radiation chemistry, Academia Praha, 1990.

Wishart J.F., Rao B.S.M. (ed) Recent trends in Radiation Chemistry. World Scientific Publishing, London 2010

Note:

Time-table for winter semester 2011/2012:

Time-table is not available yet

Time-table for summer semester 2011/2012:

Time-table is not available yet

The course is a part of the following study plans:

• FNSPE Prospectus MGR level (!)