Radiological Physics - Radiotherapy 2

Lecturer:

Irena Koniarová (gar.)

Tutor:

Irena Koniarová (gar.)

Supervisor:

Department of Dosimetry and Application of Ionizing Radiation

Synopsis:

Clinical radiobiology - organ toxicity criteria, TCP and NTCP models, Intensity Modulated RadioTherapy - optimization, dose delivery methods - compensators, multileaf collimators, special methods (MIMIC, tomotherapy). Dose calculation algorithms based on empirical factors, modelling (point kernel models, pencil kernel models), particle transport. Inhomogeneity correction algorithms - (not) accounting for scattered radiation. Dose distribution verification - anatomic phantoms, 1D, 2D and 3D dosimetry methods. Alternative therapeutic methods - photodynamic therapy, hyperthermia. Hadron radiotherapy - biological effects, comparison with conventional radiotherapy, technical aspects (cyclotron, synchrotron, beam modulation, dosimetry). Technical norms and legislation (acceptance tests, commissioning, audits).

Requirements:

16RFRT1, 01RMF

Syllabus of lectures:

1.CLINICAL RADIOBIOLOGY

2.CLINICAL RADIOBIOLOGY-MODELS

3.IMRT-OPTIMIZATION

4.IMRT-PHYSICAL REALISATION, INSTRUMENTATION

5.IMRT-PRACTICAL DEMONSTRATION

6.DOSE CALCULATION ALGORITHMS-EMPIRICAL PHACTORS

7.INHOMOGENEITY CORRECTION ALGORITHMS

8.DOSE CALCULATION ALGORITHMS-MODEL BASED

9.DOSE VERIFICATION

10.ALTERNATIVE THERAPEUTIC METHODS

11.HADRON RADIOTHERAPY

12.HADRON RADIOTHERAPY-TECHNICAL ASPECTS

13.TECHNICAL NORMS AND LEGISLATION

Syllabus of tutorials:

1. Biological treatment planning.

2. Algorithms vs. stochastic. deterministic-examples, vs. physical. biological optimization.

3. Present methods for inverse planning in the planning system.

4. Clinical examples, demonstration of the advantages / disadvantages compared with conventional radiotherapy.

5. Quantitative methods for dose distribution verification, verification of benefits from portal images.

6. Physical and technical implementation, the use of the cyclotron, synchrotron, Modulation volumes, treatment planning.

Study Objective:

Knowledge:

Knowledge about methods using for clinical radiobiology and radiotherapy.

Abilities:

Using knowledge to verify dose distributions in phantoms with conventional radiotherapy. Using algorithms to correct for homogeneity, taking into account scattering.

Study materials:

Key references:

[1]Faiz M. Khan, The Physics of Radiation Therapy

[2]Jacob Van Dyk, The Modern Technology of Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncologists

Recommended references:

[3]Steve Webb, et al, The Physics of Conformal Radiotherapy: Advances in Technology (Medical Science Series) 1997

[4]G. Steel, Basic Clinical Radiobiology 2002)

Note:

Time-table for winter semester 2011/2012:

Time-table is not available yet

Time-table for summer semester 2011/2012:

Time-table is not available yet

The course is a part of the following study plans: