Advanced Methods for Diagnostic Imaging

Lecturer:

Tutor:

Supervisor:

Department of Natural Sciences

Synopsis:

The course consists of two parts. The first one, delivered by Christoph Rose-Petruck from Brown University, Providence, U.S.A ., concernes of X-ray science for diagnostic imaging. The second one tought by prof. Norbert Lange, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne is devoted to Optical Methods for Molecular Imaging: Preclinical and Clinical Advances.

Two introductory and closing lectures will be presented by CTU FBME professors Pavel Kučera and Vlastimil Fidler.

Requirements:

Syllabus of lectures:

1. Introduction

2. X-ray sources.

3Fundamental x-ray interactions (absorption, scatter) with tissue and contrast agents

4X-ray image formation theory

5X-ray image contrast

6X-ray imaging instruments

7X-ray imaging modalities (x-ray projection imaging, computed tomography)

8 Radiation safety and patient dose considerations

9Optical Contrast Agents I

10Optical Contrast Agents II

11Conceiving imaging devices for clinical fluorescence imaging

12Some Contrast Agents can be used as theranostics: Photosensitizers

13Some Contrast Agents can be used as theranostics: Photodynamic Therapy in clinical practice

14 Test. Assessment

Syllabus of tutorials:

Study Objective:

The part „X-ray science for diagnostic imaging “ will provide topics: x-ray sources, fundamental x-ray interactions (absorption, scatter) with tissue and contrast agents, x-ray image formation, x-ray image contrast, x-ray imaging instruments, x-ray imaging modalities (x-ray projection imaging, computed tomography, x-ray scatter imaging), radiation safety and patient dose considerations.

The part "Optical Methods for Molecular Imaging: Preclinical and Clinical Advance? will provide a comprehensive educational experience in the physics, chemistry, engineering, and physiology that underlie the molecular imaging. Conventional imaging technologies often lack the resolution needed for reliable diagnosis. New optical methodologies are able to image down to thousand cells in a clinical setting. This class is intended to bring course attendees to the state-of-the-art in the field of fluorescence imaging.

Study materials:

[1] Jerrold T. Bushberg, J. Anthony Seibert, Edwin M. Leidholdt Jr., John M. Boone, The Essential Physics of Medical Imaging, Lippincott Williams & Wilkins, 2001, ISBN: 0683301187

[2] Textbook of in Vivo Imaging in Vertebrates Vasilis Ntziachristos, Anne Leroy-Willig, Bertrand Tavitian, Wiley. Photosensitizers in Medicine, Environment, and Security Tebello Nyokong, Springer 2012.

[3] Handbook of Fluorescence Spectroscopy and Imaging: From Ensemble to Single Molecules Markus Sauer Johan Hofkens, Jörg Enderlein Wiley 2011

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: