Organic chemistry and biochemistry

Lecturer:

Tutor:

Supervisor:

Department of Natural Sciences

Synopsis:

Subject is focused on the problematics of organic chemistry and biochemistry, i.a. with particular focus on electronic structure, stereochemistry, chemical reactivity, reaction mechanisms, important natural species, and organic analysis.

Requirements:

Credit condition: attendance min. 70%, succesfull passing of 2 written tests, basic biochemical compounds formulae

Syllabus of lectures:

1.Chemical bond, molecular orbitals, sigma a pi bonds, conjugation, resonance, stability of molecules, shapes of molecules, bond polarity , intermolecular interactions

2.Nomenclature of organic chemistry, functional groups, isomerism, conformations, chirality

3.Acids and bases, Arrhenius, Bronsted-Lowry and Lewis theory, organic ions a radicals and their stability

4.Basic kinds of organic reactions, reaction kinetics, chemical equilibrium, thermochemistry, kinetically a termodynamically controlled reactions

5.Alifatic a cyclic alkanes, alkenes and alkynes, their stereochemistry, aromatic compounds

6.Oxygen containing compounds: ethers, alcohols, ketones, aldehydes and carboxylic acids

7.Halogenides, organometallic compounds, compounds containing sulphur

8.Nitrogen compounds: amines, nitro- and nitroso- compounds

9.Carboxylic acid derivatives: esters, amides, halogenides, anhydrides and nitriles

10.Aminoacids, peptides and proteins

11.Heterocyclic compounds and nucleic acids

12.Carbohydrates, lipids, terpenes, steroids

13. Metabolisms ofsacharides and lipids

14.Organic analysis, separation methods, chromatography, mass spectrometry. UV-Vis, vibrational and NMR spectroscopy

Syllabus of tutorials:

none

Study Objective:

The main aim of this subject is to provide an integrative explanation of the fundamentals of organic chemistry and biochemistry of biopolymers.

Study materials:

Basic literature:

[1] Brown W.H., Poon T.: Introduction to Organic Chemistry, 3rd Edition, Wiley 2004,

[2] Trnka T. a kol.: Organická chemie pro posluchače nechemických oborů, Karolinum Praha 2003,

[3] Pacák J.: Úvod do studia organické chemie, SNTL Praha 1982

[4] CD ROM Encyklopedie 2004 - Biochemie (20 pcs available in library of FBMI CVUT)

Recomended literature:

[1] Štern, P. a kol: Obecná a klinická biochemie. Karolinum, Praha 2005

[2] Kodíček, M. Biochemické pojmy - výkladový slovník. Praha, Vydavatelství VŠCHT, 2004

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Navazující magisterský studijní obor Přístroje a metody pro biomedicínu (compulsory elective course)