Physical Chemistry

Grading of the course requires grading of the following courses:

Chemistry (17ABBCHM)

Lecturer:

Tutor:

Supervisor:

Department of Biomedical Technology

Synopsis:

Mixtures of compounds. Vapour and vaporisation. Electrodes. Electrochemical potential, electrodes. Referent and measuring electrodes, ECG, EEG and EMG electrodes. Redox potential. Inert electrodes. Membranes. Osmotic pressure. Ion-sensitive electrodes. Acidity. Measurement of pH, pO2, pCO2. Electrolysis and its application. Corrosion and protection of implants. Other amalytical methods based on principles of physical chemistry.

Requirements:

Syllabus of lectures:

1. Objectives of the subject. Basic principles of physical chemistry. Physical and chemical properties of compounds. Basic calculations.

2. Mixtures of compounds-gases.

3. Mixtures of compounds-solid and liquid compounds.

4. Evaporation, saturated vapour. Humidifiers and vaporizers of anaesthetic compounds.

5. Electrochemical potential, electrodes. Nernst equation. Electrodes of the first type. Electrochemical cell and half-cell. Application in biomedical engineering.

6. Electrodes of the second type. Solubility product. Reference electrodes. ECG, EEG and EMG electrodes.

7. Redox potential. Inert electrodes. Calculation of redox potential. Application in BME.

8. Membranes-types, properties and application. Osmotic pressure. Ion-sensitive electrodes. Acidity of solutions, pH. Measurement of pH.

9. Stability of materials and corrosion. Anodic reactions. Corrosive speed.

10. Electrolysis, conductivity of solutions and its measurement. Other methods for analysis of solutions and gases. Applications in BME.

11. Optical absorption. Spectrophotometry, etc. Application in BME.

12. Fluorescence a phosphorescence. Sensors for pH, pO2, pCO2 and SO2 measurement based on optical principles.

13. Advanced analytical methods and equipment. Mass spectroscopy, nuclear magnetic resonance, atomic absorption spectrophotometry, etc.

14. Thermodynamics-basic principles and calculations.

Syllabus of tutorials:

1. Chemical laboratory-equipment and usage. Safety in the laboratory, safety procedures.

2. Basic calculations in physical chemistry. Calculations with gases. Calculations from chemical equations.

3. Experiments confirming calculations from chemical equations-solid compounds.

4. Experiments confirming calculations from chemical equations-liquids.

5. Experiments confirming calculations from chemical equations-gaseous compounds.

6. Electrolysis of solutions.

7. Well-defined potentials. Measurement of electrodes of the first type.

8. Measurement of pH. Laboratory preparation of pH standards. Calibration of pH-measuring system.

9. Measurement of redox potentials.

10. Experiments with fluorescence and phosphorescence.

11. Optical analytical methods, spectrophotometric measurements.

12. Measuremnt of conductivity.

13. Titration based on conductivity.

14. Analysis using AAS.

Study Objective:

The aim of the subject is to give students the basic principles of the physical chemistry that are essential for design and work of the medical equipment, in clinical trials and in clinical practice. Application of these principles in the practice is explained.

Study materials:

[1] Atkins, P., Paula, J.: Atkins' Physical Chemistry. (Eighth Edition). Oxford University Press, Oxford, 2006.

[2] Raff, M. L.: Principles of Physical Chemistry. (Paarts 1 and 2). Prentice Hall, Upper Saddle River, 2001.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Bakalářský studijní obor Biomedicínský technik v AJ (compulsory course)