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CZECH TECHNICAL UNIVERSITY IN PRAGUE
STUDY PLANS
2011/2012

Fundamentals of Pharmacology

The course is not on the list Without time-table
Code Completion Credits Range Language
17AMSZF KZ 4 2+1+1
Lecturer:
Tutor:
Supervisor:
Department of medical branches and humanities
Synopsis:

The course introduces the general principles and concepts in pharmacology, mechanisms of action of individual groups of drugs and their therapeutic use. Emphasis will be placed on the ability of students to orientate themselves in drug databases, search for self-relevant information and methods of clinical evaluation of new drugs. Acquired knowledge should enable students to better communicate with health professionals in the field of pharmacotherapy and testing of new drugs.

Requirements:

Credit: 100% active participation, the test - at least 80% correct answers

Test: test - at least 80% correct responses in the range of literature and reference

lectured

When repeating a test or oral exam

(sets of questions are available on the website of the Department)

Note: The interval between regular and repeat the test or tests must be provisioned at least 7 days.

Syllabus of lectures:

1st topic - Introduction, organizational issues. Introduction to pharmacology, general concepts v.s. Special pharmacology,pharmacokinetics, pharmacodynamics, drug. Types of drug therapy (treating the cause, replacement therapy ....). Sources of drugs, nomenclature, sources of information about drugs. Pharmacopoeia, AISLP, Med-line, registration of drugs, LEAFLET

Pharmacodynamics: drug effects at molecular, tissue and system (ligand-receptor binding, competitive, uncompetitive,partial agonist, antagonist affinity, classification of receptors).

2nd topic - Pharmacokinetics

Factors determining patient response to LP (physical and chemical properties of drugs, dosage form, age, sex, body weight, pathology, genetic factors, dose) desirable and undesirable effects, indications and contraindications, drug interactions, therapeutic drug monitoring, evaluation of response to treatment. Types of applications of drugs, i.v., i.m., S.C., p.o. Basic pharmacokinetic parameters

3rd topic - Special theme of Pharmacology

Substances affecting the autonomic nervous system (sympathetic parasympathetic, cholinomimetika, antimuscarinic and anticholinergic compounds, sympathomimetics, sympatholytics)

4th topic - Substances affecting CNS (antidepressants, antipsychotics, anticonvulsants, hypnotics, sedatives, psychostimulants). Analgesics, anti-inflammatory

5th topic - Pharmaceuticals diseases of the digestive tract,respiratory tract diseases.

Drugs affecting the cardiovascular system

6th topic - Antibiotics, anti-tumor drugs, antivirals

Hormones, autakoidy, immunomodulators

7th topic - Methodology for clinical evaluation of LP, the organization KH by good clinical practice.

KH Design (Phase I - IV), data analysis in clinical trials

Ethics of medical research bodies and institutions participating in the KH

Syllabus of tutorials:

1st topic - Computer programs and databases, pharmacopoeia, SIDC, EMEA, PIL, SPC, AISLP

2nd topic - Pharmacokinetics, autonomic NS, or simulation ileum

Test No. 1 - General Pharmacology, nervous system

3rd topic - Pain and inflammation, cancerous pain.

4th topic - Pharmaceuticals diseases of the digestive tract, respiratory tract diseases

5th topic - Cardiovascular system

Test No. 2 - Drugs CNS, gastrointestinal, respiratory diseases, painkillers

6th topic - ATB

7th topic - Clinical evaluation of the topic, the use of the database LEAFLET

Each topic are given two exercises.

Entering the individual work: student will prepare a paper on the topic, which agrees with the leading practices.

Paper for presentation at an agreed following seminar (pharmacodynamics)

Study Objective:
Study materials:

Recommended Literature:

Referencní literatura:

[1] Martínková J. et al:: Farmakologie pro studenty zdravotnickych oboru, Grada, 2007

[2] Strnadová V. a spol.: Uvod do metodiky klinického hodnocení lécivych prípravku ,Grada 2007

Doporucená literatura:

[1] Lullmann H a spol. :Barevny atlas farmakologie - preklad 5. vydání, Grada Publishing 2006

[2] Lincová D., Farghali H., (ed.) : Základní & klinická farmakologie - - 2.vyd. - Galén 2006

[3] Lullman H., Mohr K., Wehling M. :Farmakologie a toxikologie - 2. ceské vydání (preklad 15. orig. vyd.), - Grada, 2004

Note:
Further information:
No time-table has been prepared for this course
The course is a part of the following study plans:
Generated on 2012-7-9
For updated information see http://bilakniha.cvut.cz/en/predmet2154106.html