Fundamentals of Pharmacology
| Code | Completion | Credits | Range | Language |
|---|---|---|---|---|
| 17MKZF | Z,ZK | 5 | 2+1+1 | Czech |
- Lecturer:
- Jan Pokorný (gar.)
- Tutor:
- Marián Liberko
- Supervisor:
- Department of medical branches and humanities
- Synopsis:
-
The course introduces the general principles and concepts in pharmacology, mechanisms of action of individual groups of drugs and their therapeutic use. Emphasis will be placed on the ability of students to orientate themselves in drug databases, search for self-relevant information and methods of clinical evaluation of new drugs. Acquired knowledge should enable students to better communicate with health professionals in the field of pharmacotherapy and testing of new drugs.
- Requirements:
-
credit:
Terms of credit: participation in exercises, elaboration of a given paper, the student raised a passing inspection tests.
examination:
The test is written (verbal correction),80 % success rate. The total evaluation will also include the results of control tests during the semester. Details will be communicated to the first lecture.
caution: intervals between repeated examinations must not be shorter than seven days
- Syllabus of lectures:
-
1.st topic - Introduction, organizational issues. Introduction to pharmacology, general concepts v.s. Special pharmacology,pharmacokinetics, pharmacodynamics, drug. Types of drug therapy (treating the cause, replacement therapy ....). Sources of drugs, nomenclature, sources of information about drugs. Pharmacopoeia, AISLP, Med-line, registration of drugs, LEAFLET
Pharmacodynamics: drug effects at molecular, tissue and system (ligand-receptor binding, competitive, uncompetitive,partial agonist, antagonist affinity, classification of receptors).
2.nd topic - Pharmacokinetics
Factors determining patient response to LP (physical and chemical properties of drugs, dosage form, age, sex, body weight, pathology, genetic factors, dose) desirable and undesirable effects, indications and contraindications, drug interactions, therapeutic drug monitoring, evaluation of response to treatment. Types of applications of drugs, i.v., i.m., S.C., p.o. Basic pharmacokinetic parameters
3.rd topic - Special theme of Pharmacology
Substances affecting the autonomic nervous system (sympathetic parasympathetic, cholinomimetika, antimuscarinic and anticholinergic compounds, sympathomimetics, sympatholytics)
4.th topic - Substances affecting CNS (antidepressants, antipsychotics, anticonvulsants, hypnotics, sedatives, psychostimulants). Analgesics, anti-inflammatory
5.th topic - Pharmaceuticals diseases of the digestive tract,respiratory tract diseases.
Drugs affecting the cardiovascular system
6.th topic - Antibiotics, anti-tumor drugs, antivirals
Hormones, autakoidy, immunomodulators
7.th topic - Methodology for clinical evaluation of LP, the organization KH by good clinical practice.
KH Design (Phase I - IV), data analysis in clinical trials
Ethics of medical research bodies and institutions participating in the KH
- Syllabus of tutorials:
-
1.st topic - Computer programs and databases, pharmacopoeia, SIDC, EMEA, PIL, SPC, AISLP
2.nd topic - Pharmacokinetics, autonomic NS, or simulation ileum
Test No. 1 - General Pharmacology, nervous system
3.rd topic - Pain and inflammation, cancerous pain.
4.th topic - Pharmaceuticals diseases of the digestive tract, respiratory tract diseases
5.th topic - Cardiovascular system
Test No. 2 - Drugs CNS, gastrointestinal, respiratory diseases, painkillers
6.th topic - ATB
7.th topic - Clinical evaluation of the topic, the use of the database LEAFLET
Each topic are given two exercises.
Entering the individual work: student will prepare a paper on the topic, which agrees with the leading practices.
Paper for presentation at an agreed following seminar (pharmacodynamics)
- Study Objective:
-
The main aim of this course is to explain the basics and practical aspects of pharmacology, including the relationship to modern information technologies.
- Study materials:
-
Recommended Literature:[1]. Farmakologie pro studenty zdravotnických oborů - Martínková J. a kol. Grada 2007 [2].Úvod do metodiky klinického hodnocení léčivých přípravků - [Strnadová V. a spol., Grada 2007Other possible Literature:[3].Barevný atlas farmakologie - Lullmann H a spol., překlad 5. vydání, Grada Publishing 2006 [4].Základní & klinická farmakologie - Lincová D., Farghali H., (ed.) - 2.vyd. - Galén 2006 [5].Farmakologie a toxikologie - Lullman H., Mohr K., Wehling M. 2. české vydání (překlad 15. orig. vyd.), - Grada, 2004 [6].Pharmacology - H. P. Rang, et al. - 6th ed. - Churchill Livingstone, 2007 [7].Pharmacology Condensed Dale NN, Haylett DG, Churchill Livingstone, 2004 [8].Basic & clinical pharmacology - B. G. Katzung - 10th ed. - Lange Medi. Books - McGraw-Fill 2007
- Note:
- Time-table for winter semester 2011/2012:
- Time-table is not available yet
- Time-table for summer semester 2011/2012:
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06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon Tue Fri Thu Fri - The course is a part of the following study plans: