Radiobiology

Lecturer:

Tutor:

Supervisor:

Department of medical branches and humanities

Synopsis:

The target of the subject is explanation of radiobiological principles of different types of the external radiation damage and contamination with radioactive substances, explanation of dependences of biological effects on the type and dose of radiation, on the dose distribution with time, dose distribution in the organism and importance of recovery processes. Attention will be paid to different pathogenic forms of the acute post-irradiation syndrome, their periodic nature in the clinical pattern and furthermore to the diagnostics, prophylaxis and treatment of this disease. The students will be acquainted with the risk of chronic post-irradiation syndrome and with late and genetic consequences of irradiation, they will be familiarized with growth disorders and teratogenic effects of ionizing radiation. The students will also be acquainted with sources, forms, effects and clinical forms of the use of non-ionizing types of radiation. Attention will be particularly paid particularly to those forms, which are most frequently used in medicine and industry - laser, electromagnetic field, electric field.

Requirements:

Tutorials,Examination:

100% participation in practical exercises (tutorials),

demonstration of the knowledge mastered by a written test,

passing the examination by the method set.

Syllabus of lectures:

Lectures:

1st - 2nd weeks Importance of radiobiological knowledge in limiting and control of ionizing radiation exposures.

3rd - 4th weeks Pathogenic forms of the acute post-irradiation syndrome.

5th - 6th weeks Early and late consequences of the external and internal contamination with radioactive substances.

7th - 8th weeks Prophylaxis and treatment of radiation damage.

9th - 10th weeks Laser, types of laser media.

11th - 12th weeks Biological effects of laser.

13th Biological effects of the electromagnetic field.

Tutorials:

1st - 2nd weeks Biophysical units important in considering the severity of radiation damage.

3rd - 4th weeks Primary mechanisms of biological effects of ionizing radiation.

5th - 6th weeks Correction of sublethal radiation damage and estimate of tolerance to further irradiation.

7th - 8th weeks Ionizing radiation dose - effect relationship. Estimate of radiation damage.

9th - 10th weeks Effects of ionizing radiation on the human reproduction.

11th - 13th weeks Principles of the protection from radiation.

Syllabus of tutorials:

Tutorials:

1st - 2nd weeks Biophysical units important in considering the severity of radiation damage.

3rd - 4th weeks Primary mechanisms of biological effects of ionizing radiation.

5th - 6th weeks Correction of sublethal radiation damage and estimate of tolerance to further irradiation.

7th - 8th weeks Ionizing radiation dose - effect relationship. Estimate of radiation damage.

9th - 10th weeks Effects of ionizing radiation on the human reproduction.

11th - 13th weeks Principles of the protection from radiation.

Study Objective:

Targets:

to master basic knowledge within the subject to the extent necessary for the performance of the profession in the branch Radiology Assistant.

Study materials:

Mandatory Literature:

Kuna, P., Navrátil, L. a kol.: Klinická radiobiologie, MANUS, Praha, 2005

Kolektiv autorů: Moderní fototerapie a laseroterapie. MANUS Praha 2000

Recommended Literature:

Neruda, O.: Radiační události. In: Štětina, J. a spolupracovníci: Medicína katastrof a hromadných neštěstí. Grada Publishing, Praha, 2000

Butomo, I.V. et al.: Osnovy medicinskoj radiobiologii. Foliant, Sankt Peterburg, 2004

Iljin L.A. et al.: Radiacionnaja medicina. IzdAT, Moskva, 2001

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: