Radiobiology

Lecturer:

Jozef Sabol (gar.), Marián Liberko, Leoš Navrátil

Tutor:

Jozef Sabol (gar.), Marián Liberko, Leoš Navrátil

Supervisor:

Department of medical branches and humanities

Synopsis:

The target of the subject is explanation of radiobiological principles of different types of the external radiation damage and contamination with radioactive substances, explanation of dependences of biological effects on the type and dose of radiation, on the dose distribution with time, dose distribution in the organism and importance of recovery processes. Attention will be paid to different pathogenic forms of the acute post-irradiation syndrome, their periodic nature in the clinical pattern and furthermore to the diagnostics, prophylaxis and treatment of this disease. The students will be acquainted with the risk of chronic post-irradiation syndrome and with late and genetic consequences of irradiation, they will be familiarized with growth disorders and teratogenic effects of ionizing radiation. The students will also be acquainted with sources, forms, effects and clinical forms of the use of non-ionizing types of radiation. Attention will be particularly paid particularly to those forms, which are most frequently used in medicine and industry - laser, electromagnetic field, electric field.

Requirements:

Credit: Active participation in seminars, including home preparation, required 100% attendance at seminars, absence can be excused only for serious and documented reasons for agreement with the exercises. The method of compensation shall exercise teacher. In addition, at least one paper on practical exercises to the designated topic.

Examination: oral, topical areas will be published at the end of the semester. The test will consist of written part of the contents of lectures, exercises and given a separate study. In the test, the student may use literature, Internet, mobile phone or consult with other students. The oral part is only in the case of an ambiguous assessment test or if the student wants to get better ranking trademark.

The written portion of the combined test is:

- ABC-type answers (possibly more correct answers) - correctly answered question 1 point

- The answer when it is necessary to respond in writing (very important issues) - 5 points

Students can reach the maximum number of 80 points, with the successful passing of the examination is necessary to reach 60 points (75%) and more.

Rating ECTS:

A good 100-90 (excellent)

B 89-80 very good (very good)

C 79-70 well (good)

D 69-60 satisfactory (satisfactory)

E 59-50 enough (sufficient)

F 49-0 failed (failed)

note: the interval between regular and repeat the test or tests must be provisioned at least seven days.

Syllabus of lectures:

Lectures:

Importance of radiobiological knowledge in limiting and control of ionizing radiation exposures.

Pathogenic forms of the acute post-irradiation syndrome.

Early and late consequences of the external and internal contamination with radioactive substances.

Prophylaxis and treatment of radiation damage.

Laser, types of laser media.

Biological effects of laser.

Biological effects of the electromagnetic field.

Syllabus of tutorials:

Tutorials:

Biophysical units important in considering the severity of radiation damage.

Primary mechanisms of biological effects of ionizing radiation.

Correction of sublethal radiation damage and estimate of tolerance to further irradiation.

Ionizing radiation dose - effect relationship. Estimate of radiation damage.

Effects of ionizing radiation on the human reproduction.

Principles of the protection from radiation.

Study Objective:

Targets:

to master basic knowledge within the subject to the extent necessary for the performance of the profession in the branch Radiology Assistans.

Study materials:

[1] Kuna P., Navrátil, L. a kol.: Klinická radiobiologie, MANUS, Praha, 2005

[2] Kolektiv autorů: Moderní fototerapie a laseroterapie. MANUS, Praha 2000

[3] Matoušek, J., Österreicher, J., Linhart, P.: CBRN - jaderné zbraně a radiologické materiály. SPBI, Ostrava, 2007, 216 s ISBN 978-80-7385-029-6

[4] Matoušek, J., Urban, I., Linhart, P.: CBRN - detekce a monitorování, fyzická ochrana, dekontaminace. SPBI, Ostrava, 2008, 232 s., ISBN 978-80-7385-048-7

[5] Neruda, O.: Radiační události. In: Štětina, J. a spolupracovníci: Medicína katastrof a hromadných neštěstí. Grada Publishing, Praha, 2000

[6] Butomo, I.V. et al.: Osnovy medicinskoj radiobiologii. Foliant, Sankt Peterburg, 2004

[7] Iljin L.A. et al.: Radiacionnaja medicina. IZDAT, Moskva, 2001Klener, V. et al.: Principy a praxe radiační ochrany, SÚJB, Praha, 2000

Note:

Time-table for winter semester 2011/2012:

	06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon
Tue	roomKL:GDM6 Sabol J. Navrátil L. 12:00–13:50 (lecture parallel1) Kladno FBMI Učebna GDM6_20
Fri
Thu	roomKL:GDM4 Liberko M. 14:00–15:50 ODD WEEK (lecture parallel1 parallel nr.101) Kladno FBMI Učebna GDM4_301
Fri

Time-table for summer semester 2011/2012:

Time-table is not available yet

The course is a part of the following study plans:

• Bakalářský studijní obor Radiologický asistent - prezenční (compulsory course)