Biomaterials

Lecturer:

Tutor:

Synopsis:

The syllabus consists of two parts: materials whose synthesis and/or design of structure are bio-inspired and materials for implants and artificial organs. The first part is focused on the formation, function, and structural characterization of bio-mimetic materials; the second part is an introductory into the relations between internal structure properties, application technology of processing and characterization of new biomaterials for medical devices, artificial implants and artificial organs.

Requirements:

Syllabus of lectures:

1. Physical chemistry of biomaterials. Self-similarity and self-afinity, percolation, sol-gel transformation, diffusion-limited aggregation and growth, growth of organic structures

2. Colloids. Van der Waals forces, forces of electrostatic origin, chaos, processes of coagulation, kinetics, thermodynamics and morphology of colloidal aggregates, spontaneous growth of colloidal fractal and its control

3. Isoelectric point, amphiphilic molecules and surfactants, interfacial films and spontaneous curvature, formation, morphology and properties of lamellar, cylindrical, spherical and complex micelles, vesicles and liposomes

4. Supramolecular and biological self-assembly

5. Tissue engineering. In vitro tissue growth and replantation

6. Biomineralization. Formation, structure, and properties of biominerals

7. Biological nanomaterials. Ferritins and related proteins. Magnetotactic bacteria.

8. Electrochemical sensors, immunosensors, biosensors

9. Structure and properties of organic/inorganic interface. Biocompatibility (definitions and issues)

10. Materials for implants and artificial organs.

11. Structure, properties and processing of implant materials

12. Behavior of implant materials in physiological environments. Molecular and supramolecular transformations, chemical and electrochemical corrosion and dissolution, swelling and leaching

13. Mechanical behavior of materials in physiological environments. Deformation and failure, friction and wear

14. Test methods for biological performance. In vitro test methods, in vivo implant models, clinical testing of implant materials

Syllabus of tutorials:

1. Evaluation of mechanical properties of biomaterials

2. Evaluation of mechanical properties of biomaterials

3. Evaluation of electrical properties of biomaterials

4. Evaluation of electrical properties of biomaterials

5. Evaluation of electrical potential generated by biomaterial when stressed

6. Evaluation of electrical potential generated by biomaterial when stressed

7. Diffusion limited growth of fractal clusters - experimental demonstration

8. Diffusion limited growth of fractal clusters - experimental demonstration

9. Case study: Ceramic and metallic materials in orthopedics - new insights and comparison

10. Case study: Ceramic and metallic materials in orthopedics - new insights and comparison

11. Excursions: Clinical application of implants

12. Excursions: Clinical application of implants

13. Excursions: Biomaterials processing

14. Excursions: Biomaterials processing

Study Objective:

Study materials:

1. Biomaterials and Bioengineering Handbook, Ed. by Donald L. Wise, Cambridge Scientific Inc., Cambridge, Massachusetts 2000. Dekker 2000.

2. Jonathan Black (Clemson Univ., South Caroline), Biological Performance of Materials (Fundamentals of Biocompatibility), 3rd ed., Dekker 1999

3. M. Daoud, Claudine E. Williams, Soft Matter Physics, Springer 1995

4. Nanomaterials: Synthesis, Properties and Applications. ed. By Edelstein, A.S. and Cammarata, R.C. The Institute of Physics, London 1998.

5. Madou,M: Fundamenrtals of Microfabrication. CRC Press New York 1997

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Heavy-current Engineering - Electroenergetics- structured studies (elective specialized course)
• Telecommunications and Radio-engineering - High-frequency and Microwave Technology- structured studi (elective specialized course)
• Heavy-current Engineering - Technological Systems- structured studies (elective specialized course)
• Cybernetics and Measurements - Control Engineering- structured studies (elective specialized course)
• Electronics - Electronic Systems- structured studies (elective specialized course)
• Economics and Management of Power Engineering- structured studies (elective specialized course)
• Biomedical Engineering- structured studies (elective specialized course)
• Economics and Management in Electrical Engineering- structured studies (elective specialized course)
• Electronics - Electronic Applications- structured studies (elective specialized course)
• Electronics - Electronics and Photonics- structured studies (elective specialized course)
• Cybernetics and Measurements - Artificial Intelligence- structured studies (elective specialized course)
• Cybernetics and Measurements - Measurement and Instrumentation Systems- structured studies (elective specialized course)
• Cybernetics and Measurements - Aeronautical Engineering and Control Systems- structured studies (elective specialized course)
• Heavy-current Engineering - Electric Drives- structured studies (elective specialized course)
• Heavy-current Engineering - Electrical Engineering Applications- structured studies (elective specialized course)
• Telecommunications and Radio-engineering - Opto-electric Systems- structured studies (elective specialized course)
• Telecommunications and Radio-engineering - Radio Communications, Navigation and Radar Systems- struc (elective specialized course)
• Telecommunications and Radio-engineering - Multimedia, Sound and Television Technology- structured s (elective specialized course)
• Telecommunications and Radio-engineering - Telecommunications- structured studies (elective specialized course)