Biometry and Statistics

The course is a substitute for:

Biometry and Statistics (X33BOS)

Lecturer:

Tutor:

Supervisor:

Department of Cybernetics

Synopsis:

Aim of the course is to explain methodology to be followed when statistical methods are applied in medicine. Problems concerning planning, realization and statistical evaluation of clinical and animal studies. Estimation of parameters and hypothesis testing. Special attention will be dovoted to GCP (Good Clinical Practice) directive, structure of a standard study as well as ethical aspects of clinical studies and problems of quality control of their execution.

Requirements:

Conditions for approval: presence in seminars and labs, measurements, presentation of solved task

Syllabus of lectures:

1. Biostatistical methods, introduction

2. Data description, qualitative data, ordinal data, quantitative data

3. Estimation of parameters and hypothesis testing

4. Clinical and animal studies - introduction

5. Planning, realization and statistical evaluation of a study

6. GCP (Good Clinical Practice) directive

7. Structure of a standard study

8. Categorization of study into individual phases

9. Description of methodology of statistical planning, monitoring and statistical evaluation of studies

10. Hypothesis formulation

11. Definition of sufficient study range

12. Randomization and description of methods of explorational and confirmational analysis

13. Ethical aspects of studies

14. Problems of quälity control of their execution

Syllabus of tutorials:

1. Basic biostatistical methods

2. Examples of data and application of methods

3. Task solving

4. Task solving

5. Particular examples of clinical studies

6. Case analysis

7. Design of a study

8. Preparation of individual phases

9. Methods for study evaluation

10. Hypothesis formulation

11. Problem of study range

12. Methods of explorational and confirmational analysis

13. Discussion on ethical questions of studies

14. Methods of quality control

Study Objective:

Study materials:

[1] Fry, J. C.: Biological Data Analysis: A Practical Approach. Oxford University Press, 1993

[2] Papoulis, A.: Probability and Statistics. Prentice-Hall Englewood Cliffs, 1990

[3] Matthews, D. E., Farewell, V. T.: Using and Understanding Medical Statistics. Karger Basel, 1988

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: