Chemical Thermodynamics and Electrochemistry

Lecturer:

Tutor:

Supervisor:

Department of Radioelectronics

Synopsis:

Learning of basic knowledge from chemistry, electrochemistry, physical chemistry and thermodynamics necessary for following subjects of biomedical engineering is the main aim of the subject. It deals with chemical bases of biological phenomena and their measurement, electrodes for analysis of body liquids and biopotential recording, properties of internal body environment and their measurement, osmosis, diffusion, thermodynamics of biochemical reactions, materials for BME, etc. Finally, it deals with assurance of experiments and so called „Good Laboratory Practice“.

Requirements:

Syllabus of lectures:

1. Chemistry and biological object. Basic chemical and electrochemical processes in BME

2. Chemical reactions, chemical bonds, composition and properties of solutions. Activity

3. Electrolytes

4. Composition of body liquids, chemical properties and homeostasis

5. Electrodes and electrode potential, electrochemical cell, redoxpotential

6. Definition of pH, its measurement. Effect of pH, redoxpotential and other parameters on biochemical reactions

7. Electrodes for biopotential measurements, their properties, polarisation, overpotential, rules of design

8. Biochemical analytical methods

9. Gases in solutions, solubility, equilibrium

10. Diffusion and osmosis

11. Equilibrium in chemical reactions

12. Thermodynamics of complex reactions

13. Stability and reactions of materials in BME. Corrosion

14. Principles of „Good Laboratory Practice“

Syllabus of tutorials:

1. Bases of electrochemical and biochemical experiments, proper procedures and their assurance

2. Calculations in chemistry and from chemical equations

3. Calculations in chemistry and from chemical equations. Experimental confirmation

4. Calculations of concentrations and activities, experimental confirmation

5. Calculations in electrochemistry. Electrode potentials

6. Good defined potentials

7. Poorly defined potentials

8. Properties of electrodes for biosignal recording

9. Measurement of pH

10. Properties of acids and bases

11. Biochemical analytical methods - gas concentration measurement and fluorescence analysis

12. Experiments with diffusion and osmosis

13. Equilibrium and thermodynamics

14. Materials and solutions for BME. Properties, stability, preparation and requirements

Study Objective:

Study materials:

1. Webster, J. G.: Medical Instrumentation. Application and Design. 2. ed. Boston: Houghton Mifflin Company. 1992

2. Bronzino, J. D.: The Biomedical Engineering Handbook. Boca Raton: CRC Press. 1995

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: