Fundamentals of pharmacology

Lecturer:

Tutor:

Supervisor:

Department of medical branches and humanities

Synopsis:

Origin and sources of pharmaceutical substances, drug (pharmacon), dispensatory, drugs terminology, pharmaceutical substances of vegetable origin, kinds of pharmacotherapy. Pharmacocynetics based on models, related examples, cynetics of pharmaceutical substances in organism. Detailed description of basic pharmaceutical groups and their effect mechanism in separate systems. Information technology in pharmacology.

Requirements:

Credit requirements and examination

Terms of credit: participation in exercises, elaboration of a given paper, the student raised in the context of practical exercises and passing the inspection tests.

Examination conditions: The test is written (verbal correction). The total evaluation will also include the results of control tests during the semester. Details will be communicated to the first lecture.

Syllabus of lectures:

1st Topic Introduction, organizational issues. Introduction to pharmacology, general concepts v.s. Special pharmacology, pharmacokinetics, pharmacodynamics, drug. Types of drug therapy (treating the cause, replacement therapy ....). Sources of drugs, nomenclature, sources of information about drugs. Pharmacopoeia, AISLP, Med-line, registration of drugs, LEAFLET

Pharmacodynamics: drug effects at molecular, tissue and system (ligand-receptor binding, competitive, uncompetitive, partial agonist, antagonist affinity, classification of receptors).

2nd Topic Pharmacokinetics

Factors determining patient response to LP (physical and chemical properties of drugs, dosage form, age, sex, body weight, pathology, genetic factors, dose) desirable and undesirable effects, indications and contraindications, drug interactions, therapeutic drug monitoring, evaluation of response to treatment. Types of applications of drugs, i.v., i.m., S.C., p.o. Basic pharmacokinetic parameters

3rd Special theme of Pharmacology

Substances affecting the autonomic nervous system (sympathetic parasympathetic, cholinomimetika, antimuscarinic and anticholinergic compounds, sympathomimetics, sympatholytics)

4th Topic Substances affecting CNS (antidepressants, antipsychotics, anticonvulsants, hypnotics, sedatives, psychostimulants)

Analgesics, anti-inflammatory

5th Topic Pharmaceuticals diseases of the digestive tract, respiratory tract diseases.

Drugs affecting the cardiovascular system

6th Topic Antibiotics, anti-tumor drugs, antivirals

Hormones, autakoidy, immunomodulators

7th Topic methodology for clinical evaluation of LP, the organization KH by good clinical practice.

KH Design (Phase I - IV), data analysis in clinical trials

Ethics of medical research bodies and institutions participating in the KH

Syllabus of tutorials:

1st Topic Computer programs and databases, pharmacopoeia, SIDC, EMEA, PIL, SPC, AISLP

2nd Topic pharmacokinetics, autonomic NS, or simulation ileum

Test No. 1 - General Pharmacology, nervous system

3rd Topic: Pain and inflammation, cancerous pain.

4th Topic Pharmaceuticals diseases of the digestive tract, respiratory tract diseases

5th Topic: Cardiovascular system

Test No. 2 - Drugs CNS, gastrointestinal, respiratory diseases, painkillers

6th Topic ATB

7th Clinical evaluation of the topic, the use of the database LEAFLET

Each topic are given two exercises.

Study Objective:

The aim is acquirement of essential medicine concepts to make student be able to communicate with health community of pharmacology. Another goal is to make students familiar with basic methodology of clinical pharmaceuticals testing.

Study materials:

Recommended literature:

Farmakologie pro studenty zdravotnických oborů - Martínková J. a kol. Grada 2007

Úvod do metodiky klinického hodnocení léčivých přípravků - Strnadová V. a spol., Grada 2007

Other possible literature

Barevný atlas farmakologie - Lullmann H a spol., překlad 5. vydání, Grada Publishing 2006

Základní & klinická farmakologie - Lincová D., Farghali H., (ed.) - 2.vyd. - Galén 2006

Farmakologie a toxikologie - Lullman H., Mohr K., Wehling M. 2. české vydání (překlad 15. orig. vyd.), - Grada, 2004

Pharmacology - H. P. Rang, et al. - 6th ed. - Churchill Livingstone, 2007

Pharmacology Condensed Dale NN, Haylett DG, Churchill Livingstone, 2004

Basic & clinical pharmacology - B. G. Katzung - 10th ed. - Lange Medi. Books - McGraw-Fill 2007

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Navazující magisterský studijní obor Přístroje a metody pro biomedicínu - prezenční v angličtině (compulsory elective course)