Organic chemistry

Lecturer:

Tutor:

Supervisor:

Department of Natural Sciences

Synopsis:

This course covers the problematics of organic chemistry, i.a. with particular focus on electronic structure, stereochemistry, chemical reactivity, reaction mechanisms, important natural species, and organic analysis.

Requirements:

Credit: 80% attendance,exercises development, successful management of credit test

Exam: oral examination

Syllabus of lectures:

1.Chemical bond, molecular orbitals, sigma a pi bonds, conjugation, resonance, stability of molecules, shapes of molecules, bond polarity , intermolecular interactions

2.Nomenclature of organic chemistry, functional groups, isomerism, conformations, chirality

3.Acids and bases, Arrhenius, Bronsted-Lowry and Lewis theory, organic ions a radicals and their stability

4.Basic kinds of organic reactions, reaction kinetics, chemical equilibrium, thermochemistry, kinetically a termodynamically controlled reactions

5.Alifatic a cyclic alkanes, alkenes and alkynes, their stereochemistry, aromatic compounds

6.Oxygen containing compounds: ethers, alcohols, ketones, aldehydes and carboxylic acids

7.Halogenides, organometallic compounds, compounds containing sulphur

8.Nitrogen compounds: amines, nitro- and nitroso- compounds

9.Carboxylic acid derivatives: esters, amides, halogenides, anhydrides and nitriles

10.Aminoacids, peptides and proteins

11.Heterocyclic compounds and nucleic acids

12.Carbohydrates, lipids, terpenes, steroids

13.Organic analysis, separation methods, chromatography, mass spectrometry

14.UV-Vis, vibrational and NMR spectroscopy

Syllabus of tutorials:

1) Introductory exercises

2) Electronic configuration, amount of substance

3) Molarity, recovery teams, the Lewis structure

4) Formal charge, pH

5) The structure of the molecules I

6) The structure of the molecules II, intermolecular forces

7) The foundaments of the nomenclature of organic chemistry

8) The nomenclature of aliphatic and cyclic alkanes, alkenes and alkines

9) Isomery and the Fischer´s projection, aromatic compounds

10) The nomenclature of the functional derivatives I

11) The nomenclature of the functional derivatives II

12) The nomenclature of heterocyclic compounds

13) The nomenclature of other major groups and compounds

14) Final exercises, repetition, and the granting of credits

Study Objective:

The main aim of this subject is to provide an integrative explanation of the fundamentals of organic chemistry and biochemistry of biopolymers

Study materials:

[1] Brown W.H., Poon T.: Introduction to Organic Chemistry, 3rd Edition, Wiley 2004

[2] Trnka T. a kol.: Organická chemie pro posluchače nechemických oborů, Karolinum Praha 2003,

[3] Pacák J.: Úvod do studia organické chemie, SNTL Praha 1982

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Navazující magisterský studijní obor Přístroje a metody pro biomedicínu - prezenční v angličtině (compulsory elective course)