Genetics and molecular biology
| Code | Completion | Credits | Range | Language |
|---|---|---|---|---|
| 17BOGMB | Z,ZK | 5 | 2+2 | Czech |
- Lecturer:
- Veronika Vymětalová (gar.)
- Tutor:
- Veronika Vymětalová (gar.), Taťána Jarošíková
- Supervisor:
- Department of Natural Sciences
- Synopsis:
-
General genetics: basic genetic expressions. Genotypes and Phenotypes. Mendel´s theory of inheritance. Basis of clinical genetics: heredity of genetic diseases, monogenic autosomal and gonosomal heredity and monogenic autosomal and gonosomal hereditary dominant and recessive disorders, polygenic heredity, examples of hereditary diseases. Mutagenesis: types of mutations and mutations consequences, physical, chemical and biological mutagens. Carcinogenesis, cell cycle regulation, protooncogens, tumor suppressor genes, chromosomal changes in tumors. Clinical cytogenetics. Inborn chromosomal abnormalities numerical and structural, causes of chromosomal abnormalities origin, examples of the most frequent chromosomal abnormalities. Immunogenetics, heredity of blood groups. Prenatal cytogenetic diagnosis - methods, indications, ethic problems in genetics. Molecular cytogenetics, hybridization in situ. Methods in Assisted Reproduction Technology. Molecular biology. Genetic Engineering. DNA cloning. Gene therapy.
- Requirements:
-
credit condition - 80% presence, working at laboratory, successful written test.
Examination: class ticket, succesful mastery of written work
- Syllabus of lectures:
-
1.General genetics: basic genetic expressions. Genotypes and Phenotypes.
2.Mendel´s theory of inheritance.
3.Basis of clinical genetics
4.Monogenic autosomal and gonosomal heredity, examples of hereditary diseases.
5.Polygenic heredity
6.Cell cycle regulation, protooncogens, tumor suppressor genes.
7.Mutagenesis and carcinogenesis
8.Clinical cytogenetics.
9.Prenatal cytogenetic diagnosis - methods, indications, ethic problems in genetics.
10.Molecular cytogenetics, hybridization in situ. Methods in Assisted Reproduction Technology.
11.Molecular biology.
12.Genetic Engineering. DNA cloning.
13.Gene therapy.
- Syllabus of tutorials:
-
1.General genetics.
2.Mendel´s and Morgan theory of inheritance.
3.Cell cycle, Mitosis and Meiosis.
4.Cell cycle, Mitosis and Meiosis.
5.Bacterial genetics.
6.Plant genetics and breeding. Plant genetics models. Animal genetics.
7.Clinical cytogenetics.
8.Clinical cytogenetics.
9.Monogenic autosomal and gonosomal heredity, examples of hereditary diseases
10.Monogenic autosomal and gonosomal heredity, examples of hereditary diseases
11.Polygenic heredity.Imunogenetics.
12.Mutagenesis, protooncogens, tumor suppressor genes.
13.Molecular biology.
- Study Objective:
-
general genetics, cytogenetics, gene therapy
- Study materials:
-
1) Sršeň Š., Sršňová K.: Základy klinickej genetiky a jej molekulárna podstata. Osveta. Martin 2000.
2) Kočárek E a kol.: Klinická cytogenetika I. Úvod do klinické cytogenetiky. Skripta 2. LF UK. Karolinum Praha 2006
3) Robert L. Nussbaum, Roderick R. McInnes, Huntington F.Willard:Thompson and Thompson genetics in medicine, W.B. Saunders, Philadelphia 2001, USA, ISBN 0-7216-6902-6
4) Vymětalová V.: Biologie pro biomedicíncké inženýrství I, skripta ČVUT, Praha 2008
5)Snustad D. Peter, Simmons Michael J.: Genetika, MU Brno 2009
- Note:
- Time-table for winter semester 2011/2012:
- Time-table is not available yet
- Time-table for summer semester 2011/2012:
-
06:00–08:0008:00–10:0010:00–12:0012:00–14:0014:00–16:0016:00–18:0018:00–20:0020:00–22:0022:00–24:00
Mon Tue Fri Thu Fri - The course is a part of the following study plans:
-
- Bakalářský studijní obor Optika a optometrie - prezenční (compulsory course)