Radiological Physics - Radiotherapy

Garant předmětu:

Irena Koniarová

Lecturer:

Irena Koniarová, Matěj Navrátil, Josef Novotný

Tutor:

Irena Koniarová, Tomáš Veselský

Supervisor:

Department of Dosimetry and Application of Ionizing Radiation

Synopsis:

Curriculum offers introduction to medical physics in radiotherapy. It covers basics of radiation oncology, biological effects of ionising radiation, treatment planning, units used for treatment, basic techniques of external radiotherapy and brachytherapy, quality assurance.

Requirements:

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Syllabus of lectures:

1. CLINICAL RADIOBIOLOGY: serial vs. parallel structure of organs, criteria of radiation toxicity organ.

2. CLINICAL RADIOBIOLOGY-MODELS: DVH reduction schemes, used TCP and NTCP models, EUD concept, biological treatment planning.

3. IMRT-OPTIMIZATION: optimization problem, input / output parameters of optimization process, stochastic vs. algorithms deterministic-examples, physical vs. biological optimization.

4. IMRT-PHYSICAL REALIZATION: physical realization of optimized radiation fields-compensators, multi-line collimator, MIMIC, cyber-linear accelerator - „cyberknife“.

5. IMRT-PRACTICAL DEMONSTRATION: Demonstration of the inverse planning method on the planning system, clinical examples, demonstration of advantages / disadvantages over conventional radiotherapy.

6. DOSAGE-EMPIRIC FACTOR ALGORITHMS: Percentage Depth, TPR, TAR, SAR, Output Factors, Equivalent Field Size Concept, Clarkson Integration Method for Irregular Fields.

7. NON-HOMOGENIC CORRECTION ALGORITHS: 1D methods without scattered radiation, 3D methods without scattered radiation, method scattering.

8. ALGORITHMS FOR CALCULATION OF DOSE-MODELING

9. VERIFICATION OF DOSAGE DISTRIBUTION: in-vivo dosimetry, anatomical phantoms, film dosimetry, 1D and 2D detector fields, 3D gel dosimetry

10. ALTERNATIVE THERAPEUTIC METHODS: photodynamic therapy, hyperthermia, technical implementation.

11. HADRON RADIOTHERAPY: advantages / disadvantages over conventional radiotherapy, radiobiological effect.

12. HADRON RADIOTHERAPY-TECHNICAL ASPECTS: use of cyclotron, synchrotron, treatment planning.

13. TECHNICAL-LEGAL STANDARDS AND REGULATIONS: type tests, acceptance tests, clinical trials.

Syllabus of tutorials:

The exercise follows the outline of the lectures.

Study Objective:

Knowledge:

Advanced techniques of radiotherapy, radiobiology of ionizing radiation in radiotherapy.

Abilities:

Advanced use of rediotherapeutic methods in cancer applications.

Study materials:

Key references:

[1] Faiz M. Khan, The Physics of Radiation Therapy, 2007

[2] Amy Heath, Radiation Therapy Study Guide, Springer, 2016

[3] Jacob Van Dyk, The Modern Technology of Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncologists, Steel, Washington, 2000

Recommended references:

[4] Steve Webb, et al, The Physics of Conformal Radiotherapy: Advances in Technology (Medical Science Series) 1997

[5] G. Steel, Basic Clinical Radiobiology, 2002

Note:

Time-table for winter semester 2023/2024:

Time-table is not available yet

Time-table for summer semester 2023/2024:

Time-table is not available yet

The course is a part of the following study plans:

• Radiolgická fyzika (compulsory course in the program)