Organic Chemistry 2

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

Introduction to the second group of organic compounds, carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals - industrial and natural. Introduction to the metods of structural analysis.

Requirements:

Combined witten and oral exam. Minimal score to pass the written test is 60%.

Two pre-exam tests are compulsory during semester with minimal score of 60%. Exact dates would be annonced at the beginning of the course.

Syllabus of lectures:

1.1.Carboxylic acids ? nomenclature, structure, properties, methods of preparation.

2.Carboxylic acids ? reactivity. Dicarboxylic acids, methods of preparation, their reactions.

3.Substituted carboxylic acids ? preparation, properties.

4.Halogen-, hydroxy-, oxo- and amino- acids ? nomenclature, structure, preparation, reactivity.

5.Functional derivatives of carboxylic acids ? nomenclature, structure, preparation, reactivity.

6.Esters ? condensation reactions, use in syntheses.

7.Derivatives of carbonic acid, carbamates, nitriles, isonitriles, ketenes, isocyanates, carbodiimides.

8.Heterocyclic compounds ? characterization, properties, preparation, reactivity.

9.Natural compounds ? sacharides, terpenes, steroid hormons - nomenclature, structure, properties.

10.Natural compounds ? lipides, alkaloids, secondary plant metabolites

11.Industrial organic compounds, tenzides, pesticides, pharmaceuticals.

12.Metods of structural analysis of organic compounds, basics of spectral methods.

Syllabus of tutorials:

1.Preparation and reactions of carboxylic acids.

2.Halogen-, hydroxy-, oxo-, amino- acids and their derivatives ? nomenclature, propeties, preparation and reactions.

3.Esters ? preparation, reactions and use in organic synthesis.

4.Preparation and reactions of carbonic acid derivatives.

5.Preparation, reactions and properties of heterocyclic compounds.

6.Natural compounds ? nomenclature, structure, occurence, preparation and reactions, use.

7.Industrial organic compounds ? types, use, preparation, specificity of reactions in laboratory and industrial scale.

8.Pharmaceuticals production ? history, current demands, examples of syntheses, research and development of pharmaceuticals.

9.Basics of organic compounds structural analysis, spectral methods, principles of compounds identification.

10.Identification of simple organic compounds based on provided spectral data, NMR, MS, IR methods.

Study Objective:

The course of Organic chemistry 2, provides the students with the knowledge of the second group of organic compounds that include carboxylic acids and their derivatives, heterocyclic compounds, important natural compounds, industrial organic compounds and pharmaceuticals, as well as introduction to the metods of structural analysis of organic compounds. The lecture extends the Organic chemistry 1 course.

The students will acquire competence to apprehend the advanced specialised organic chemistry courses.

Study materials:

Compulsory literature:

Smrček S., Kozempel J.: Electronic presentation Organic chemistry course, available on FNSPE website.

Other recommended literature:

McMurry J.: Organic chemistry, Brooks/Cole Cengage Learning, ISBN 9780534389994.

Lewis D.E. Organic Chemistry ? a Modern Perspective, Times Mirror Education Group, Inc. Dubunque 1996, ISBN0697350916.

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• BS Jaderná chemie (compulsory course of the specialization)