- Ondřej Lebeda (guarantor)
- Department of Nuclear Chemistry
The course introduces fundamentals of nuclear chemistry applications in
research, development and production of radiopharmaceuticals. The first part of
the course is focused on issues of appropriate radionuclide selection, general
requirements for PET and SPECT diagnostics and therapeutic radiopharmaceuticals,
ways of their application and labelling chemistry. The second part of the course
provides fundamentals of routine production and quality control of
radiopharmaceuticals (GMP rules) and discusses in detail production of a few
particular radiopharmaceuticals. In the end of the course, students will learn
about the last trends in the research of radiopharmaceuticals.
Knowledge of nuclear chemistry at the basic university course level.
- Syllabus of lectures:
1.Medicinal applications of ionizing radiation (external and internal sources of
IR, radiodiagnostics and radiotherapy).
2.Classification of radionuclides for nuclear medicine according to emitted
radiation, types of diagnostics and therapy, basic research of functions of
3.Imaging methods in nuclear medicine (gamma camera, SPECT, PET).
4.Radionuclides in diagnostics, their properties and preparation (gamma
emitters, positron emitters, preparation in neutron reactions, charged particles
reactions, generators, separation).
5.Radionuclides in therapy, their properties and preparation (beta emitters,
alpha emitters, preparation in neutron reactions, charged particles reactions,
6.Choice of RN carriers, their chemical forms, specificity and selectivity
(elementary forms, little indicator molecules, indicator macromolecules, such as
peptides and proteins - hormones, monoclonal antibodies and their fragments,
indicator micro- and nanoparticles).
7.Deposition in tissues and organs.
8.Kinetics and metabolism, optimising of combination RN-carrier (role of
kinetics and metabolism of carriers and their catabolists in relation to half-
life of RN).
9.Methods of preparation of radionuclides carriers (chemical reactions, optimum
conditions, yields, purification, quality control).
10.Behaviour of radionuclides carrier in organism - changes of metabolism,
immuno-specificities and immunoresponsiveness.
11.Basic terms in the field of routine production and quality control of
radiopharmaceuticals, GMP rules, clean rooms etc.
12.Spectrum of various methods of radiopharmaceuticals production illustrated
via discussion of production of a few widespread, routinely produced
13.Recent trends in the research of radiopharmaceuticals.
- Syllabus of tutorials:
- Study Objective:
The course Radiopharmaceuticals provides students with knowledge of principles
of research, development and production of radiopharmaceuticals.
Students will acquire grasp of basic questions of research, development
and production of radiopharmaceuticals.
- Study materials:
1.Sampson, C.B. (editor): Textbook of Radiopharmacy. Gordon and Breach Science
Publishers. Amsterdam, 1999 (3rd edition). Selected chapters.
2.Vértes, A., Nagy, S., Klencsár, Z., Lovas, R.G., Rösch, F.(eds): Handbook of
nuclear chemistry. Vol. 5 - Radiochemistry and radiopharamceutical chemistry in
life sciences. Kluwer Academic Publishers. Dordrecht, Boston, London, 2003.
1.Deckart H., Cox P. H. (eds): Principles of Radiopharmacology. Gustav Fischer
Verlag, Jena, 1987.
2.Early P. J., Sodee D. B.: Principles and Practice of Nuclear Medicine. Mosby-
Year Book, Inc., 1995.
- Time-table for winter semester 2019/2020:
- Time-table is not available yet
- Time-table for summer semester 2019/2020:
- Time-table is not available yet
- The course is a part of the following study plans:
- Jaderná chemie (elective course)