General Pharmacology

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Nuclear Chemistry

Synopsis:

Annotation In the course of General pharmacology there are taught essentials of pharmacodynamics (e.g. interactions of drugs with receptors, molecular targets for drug action), fundamentals of pharmacokinetics (e.g. the half-life and its uses), drug interactions, introduction to clinical trials of drugs, adverse drug reactions, etc. Students are also taught pharmacology of autonomous system and a prescription writing.

Requirements:

Knowledge of chemistry on the level of bachelor of chemistry and completed course of fundamentals of nuclear chemistry.

Syllabus of lectures:

1.Introduction to pharmacology, fundamental terms.

2.Supply paths of cures to organism and subsequent processes (absorption,

distribution and elimination).

3.Molecular mechanisms of cure effects. Interaction of cures with receptors.

4.Relation between dose and effect. Metabolisms of cures (biotransformation).

5.Pharmacokinetics (distribution volume, clearance, biol. half-life, time course

of cure effects).

6.Evaluation and validation of cure effects.

7.Placebo, homeopathy.

8.Pharmacogenetics.

9.Cure interactions.

10.Fundamentals of „evidence-based pharmacotherapy“.

11.Development of new cures, clinical tests, clinical studies.

12.Fundamentals of pharmacoepidemiology and pharmacoeconomics.

13.Pharmacoinformatics - sources of information about cures.

14.Undesirable effects of cures, cures during gravidity.

15.Fundamentals of pharmacovigilancy.

Syllabus of tutorials:

Study Objective:

The course provides the students with the knowledge of the fundamentals of pharmacodynamics, pharmacokinetics, drug interactions, introduction to clinical trials of drugs, etc.

The students will acquire competence to get oriented and communicate on the interface between nuclear chemistry and pharmacology.

Study materials:

Key literature:

H. P. Rang, et al.: Pharmacology, 6th ed., Churchill Livingstone, 2007.

Recommended literature:

Lullman H., Mohr K., Wehling M.: Farmakology and toxikology, Grada, 2004

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans:

• Jaderná chemie (elective course)