Radionuclide Production

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Code Completion Credits Range
15PRN ZK 2 2+0
Ondřej Lebeda (guarantor)
Department of Nuclear Chemistry

An overview of the different ways in which radionuclides may be produced (natural sources, nuclear reactions, generators). Classification of nuclear reactions (neutron, charged particles and photon induced reactions, their course, cross-sections). Calculations of radionuclide yields and their modelling for different production set-ups. Design and operation of target systems (solid, liquid and gaseous). Target processing with respect to the subsequent use of the produced radionuclide. Radionuclides generators, production, and their use.


Knowledge of nuclear chemistry on the level of a basic university course.

Syllabus of lectures:

1.Possible methods of radionuclide production (natural sources, nuclear reactions, generators), their advantages and disadvantages.

2.Nuclear reactions, their classification, cross-section, excitation functions. Characterization of the devices for radionuclides production ? nuclear reactors and accelerators.

3.Calculations of the radionuclide yields for neutron, charged particles and photon induced reactions. Important databases for production of radionuclides.

4.Modelling of radionuclide yields for different target systems and their set-ups.

5.Design, construction and operation of reactor target systems.

6.Processing of reactor targets.

7.Review of the most important reactor produced radionuclides and their use in practice.

8.Design, construction and operation of cyclotron target systems.

9.Processing of cyclotron targets.

10.Review of the most important cyclotron produced radionuclides and their use in practice.

11.Radionuclide generators and their use.

12.Technical, environmental and radiation safety aspects of radionuclides production.

Syllabus of tutorials:
Study Objective:

The course Production of Radionuclides provides students with knowledge about various ways of radionuclides?s production, calculations of the nuclear reaction yields from the primary data, about principles of design and construction of target systems, about target processing, in particular about radionuclides? separation with respect to thei further use. They will learn specific examples of routine production of radionuclides.

Students will acquire competence in design and calculation of simple, in particular cyclotron target systems taking into account major radiochemical, technical and economical requirements on operation of such systems.

Study materials:

Key literature

1.Friedlander, G., Kennedy, J.W., Macias, E.S., Miller, J.M.: Nuclear and Radiochemistry. John Wiley & Sons, Inc., 1981. Kapitoly 4, 8 a 15.

2.Cyclotron produced radionuclides: Principles and practice. IAEA Technical reports series no. 465. IAEA, Vienna, 2008.

Recommended literature

1.Cyclotron produced radionuclides: Physical characteristics and production methods. IAEA Technical reports series no. 468. IAEA, Vienna, 2009.

2.Manual for reactor produced radioisotopes. IAEA-TECDOC-1340. IAEA, Vienna, 2003.

3.Charged particle cross-section database for medical radioisotope production: Diagnostic radioisotopes and monitor reactions. IAEA-TECDOC-1211. IAEA, Vienna, 2001.

Time-table for winter semester 2018/2019:
Time-table is not available yet
Time-table for summer semester 2018/2019:
Time-table is not available yet
The course is a part of the following study plans:
Data valid to 2019-02-21
For updated information see http://bilakniha.cvut.cz/en/predmet24542905.html