Radiological Physics - Nuclear Medicine

Garant předmětu:

Lecturer:

Tutor:

Supervisor:

Department of Dosimetry and Application of Ionizing Radiation

Synopsis:

Principles of nuclear medicine, radionuclides and radiopharmacology - production, requirements and characteristics, activity and physical characteristics of radionuclides used in NM; scintigraphy - gamma camera, collimators, gamma camera parameters, optimization. Image quality in NM. Tomographic imaging in NM - SPECT, PET - radiation detectors, image acquisition and reconstruction, reconstruction methods, attenuation correction, clinical application examples. Computerized data processing in NM. QC - measuring devices parameters and methods of measurement. Methods for radiation stress determination/estimation - compartment analysis, dosimetry of internal radiation sources, effective dose estimation. In-vivo and in-vitro diagnostic methods. Radiation protection of staff members and patients, personal dosimetry, monitoring, related legislation. Technical norms and legislation (acceptance tests, commissioning, audits).

Requirements:

Required prerequisities are 16ZDOZ1, 16ZDOZ2, 16DETE, 16JRF1, 16JRF2.

Syllabus of lectures:

1. RADIONUCLIDES AND RADIOPHARMACEUTICALS.

2. RADIATION DETECTION IN NUCLEAR MEDICINE.

3. SCINTIGRAPHY.

4. NUCLEAR MEDICINE IMAGE QUALITY:

5. TOMOGRAPHICAL IMAGING, SPECT.

6. TOMOGRAPHICAL IMAGING, PET:

7. COMPUTERIZED DATA PROCESSING IN NUCLEAR MEDICINE.

8. QUALITY CONTROL.

9. RADIATION DOSES TO PATIENTS.

10. DIAGNOSTICAL METHODS IN-VIVO a IN-VITRO.

11. RADIATION PROTECTION.

Syllabus of tutorials:

1. Radiopharmaceuticals, radionuclide, chemical and pharmaceutical purity, using examples.

2. Scintillation detectors, semiconductor detectors, measurement activities, 4pi geometry.

3. Efficiency, energy resolution, liquid scintillators, the measurement statistics.

4. Apparatus for measuring in-vitro and in vivo.

5. Scintillation camera, collimator, energy properties, and spectrometric set.

6. Image quality in nuclear medicine, the spatial resolution - influencing factors, methods of evaluation.

Study Objective:

Knowledge:

Knowledge about principles of nuclear medicine and radionuclides using for radiopharmacology.

Abilities:

Determination of radiation exposure of patients, the use of compartmental analysis, the use of dosimetry of internal emitters to estimate the effective dose, dose reduction methods.

Study materials:

Key references:

[1] Physics in Nuclear Medicine by James A. Sorenson & Michael E. Phelps (Editors) (August 2003)

[2] Medizinische Physik, Bd.2, Medizinische Strahlenphysik von J. Bille, W. Schlegel Springer-Verlag Berlin Heidelberg (April 2002)

Recommended references:

[3] The Essential Physics of Medical Imaging, J.T. Bushberg et al, 2002

Note:

Further information:

No time-table has been prepared for this course

The course is a part of the following study plans: