Radiological Physics - Radiotherapy 2

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Code Completion Credits Range
16RFRT2 Z,ZK 3 2+1
Irena Koniarová (guarantor), Matěj Navrátil, Josef Novotný
Irena Koniarová (guarantor), Tomáš Veselský
Department of Dosimetry and Application of Ionizing Radiation

Curriculum offers advanced techniques of radiotherapy with the emphasis on radiobiological modelling, dose calculation algorithms, image guided radiation therapy and mathematical methods used in radiotherapy (optimisation, inhomogeneities correction).


Required prerequisities are 16RFRT1, 01RMF.

Syllabus of lectures:

1. CLINICAL RADIOBIOLOGY: serial vs parallel structure of organs, radiation toxicitiy criteria for critical structures.

2. CLINICAL RADIOBIOLOGY-MODELS: reduction schemes for DVH, used models for TCP and NTCP, concept of EUD, biological treatment planning.

3. IMRT-OPTIMIZATION: optimization problem, input/output parameters in the optimization process, stochastic and deterministic algorithms - examples, physical vs biological optimization.

4. IMRT-PHYSICAL REALIZATION: physical realization of optimized fluences of radiation fields - compensators, multileaf collimator, MIMIC, cybernetic linear accelerator Cyberknife

5. IMRT-PRACTICAL DEMONSTRATION: inverse planning in the treatment planning system, clinical examples, advantages and disadvantages in comparison to the conventional radiotherapy.

6. DOSE CALCULATION ALGORITHMS-EMPIRICAL PHACTORS: percetentage depth dose, TPR, TAR, SAR, output factors, concept of equivalent square field, Clarkson integration method for irregular fields.

7. INHOMOGENEITY CORRECTION ALGORITHMS: 1D methods without scatter modelling, 3D methods without scatter modelling, methods concerning scatter


9. DOSE VERIFICATION: in-vivo dosimetry, anatomical phantoms, film dosimetry, 1D and 2D detector fields, 3D gel dosimetry

10. ALTERNATIVE THERAPEUTIC METHODS: photodynamic therapy, hyperthermia, technical realization.

11. HADRON RADIOTHERAPY: advantages/disadvantages in comparison to the conventional radiotherapy, radiobiological effects.

12. HADRON RADIOTHERAPY-TECHNICAL ASPECTS: cyclotron, synchrotron, treatment planning.

13. TECHNICAL NORMS AND LEGISLATION: type tests, acceptance test, clinical tests.

Syllabus of tutorials:

1. Biological treatment planning.

2. Algorithms vs. stochastic. deterministic-examples, vs. physical. biological optimization.

3. Demonstration of methods for inverse planning in the planning system.

4. Clinical examples, demonstration of the advantages / disadvantages compared with conventional radiotherapy.

5. Quantitative methods for dose distribution verification, dose verification from portal dosimetry.

6. Physical and technical implementation, the use of the cyclotron, synchrotron, methods of beam modulation, treatment planning.

Study Objective:


Knowledge about advanced methods used in radiotherapy


Using knowledge to verify dose distributions in phantoms with conventional radiotherapy. Using algorithms to correct for homogeneity, taking into account scattering.

Study materials:

Key references:

[1] Faiz M. Khan, The Physics of Radiation Therapy

[2] Jacob Van Dyk, The Modern Technology of Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncologists

Recommended references:

[3] Steve Webb, et al, The Physics of Conformal Radiotherapy: Advances in Technology (Medical Science Series) 1997

[4] G. Steel, Basic Clinical Radiobiology 2002)

Time-table for winter semester 2020/2021:
Time-table is not available yet
Time-table for summer semester 2020/2021:
Time-table is not available yet
The course is a part of the following study plans:
Data valid to 2021-03-02
For updated information see http://bilakniha.cvut.cz/en/predmet24361105.html