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CZECH TECHNICAL UNIVERSITY IN PRAGUE
STUDY PLANS
2019/2020

Radiobiology

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Code Completion Credits Range
16RBIO ZK 2 2+0
Lecturer:
Marie Davídková (guarantor)
Tutor:
Supervisor:
Department of Dosimetry and Application of Ionizing Radiation
Synopsis:

The presented lectures are aimed at basis of radiation biology. Students are introduced into biological effects of ionizing radiation; physical and chemical processes of radiation action in biological material; mechanisms of radiation damage to DNA and other cell components; types of damages and their repair; subcellular and cellular sensitivity and response to irradiation; physical, biological and chemical modificators of the cell response to irradiation; theories and models for cell survival and radiation biology of normal and neoplastic tissue systems.

Requirements:

Required prerequisities are 16ZBAF1, 16ZBAF2.

Syllabus of lectures:

1. Cell structure, cell cycle and death.

2. Direct and indirect effects of ionizing radiation (IR). Radiation chemistry of water and biological systems.

3. Experimental methods for physico-chemical and chemical radiolytic processes. Deterministic and stochastic modelling of time-space development of charged particle tracks.

4. Subcellular radiobiology. DNA as critical target for radiation damage, mechanisms and types of radiation damage to DNA and proteins, reparation mechanisms.

5. Experimental methods of biological damage measurements.

6. Cell radiobiology.

7. Theoretical modelling of radiation damage at molecular level.

8. Cell survival curves. Theories and models of cell survival.

9. By-stander effect.

10. Influence of LET on cell survival. Effect of fractionation and long-term irradiation.

11. Modificators of response to irradiation: water, temperature, oxygen effect.

12. Biological and chemical modificators of response to irradiation.

13. Late effects of radiation to normal tissues. Deterministic, stochastic and genetic effects.

14. Radiation biology of normal and tumour tissues.

Syllabus of tutorials:
Study Objective:

Knowledge:

Knowledge about biological effects of ionizing radiation and physical and chemical processes of radiation action in biological material.

Abilities:

Use knowledge of the biological effects of ionizing radiation in practical applications. Minimization of exposure. Evaluation of the potential dangers of ionizing radiation.

Study materials:

Key references:

[1] Alpen E.L., Radiation Biophysics, Academic Press, San Diego, 1998

[2] Nias A.H.W., An introduction to radiobiology, Wiley, Chichester, 2000

Recommended references:

[3] Sedlak A., Microdosimetry and its applications, Academia, Prague, 1989(in Czech)

[4] Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D., Molecular Biology of the Cell, Garland Publ., New York, 1994

[5] von Sonntag C., The chemical basis of radiation biology, Taylor&Francis, London, 1987

[6] Farhataziz, Rodgers M.A.J., Radiation Chemistry: Principles and Applications,VCH Publishers, New York, 1987

[7] Scientific papers from 1990

Note:
Time-table for winter semester 2019/2020:
Time-table is not available yet
Time-table for summer semester 2019/2020:
Time-table is not available yet
The course is a part of the following study plans:
Data valid to 2020-03-31
For updated information see http://bilakniha.cvut.cz/en/predmet23986905.html